【摘要】：目的探討血清甘油三酯(triglyceride,TG)水平與急性胰腺炎(acute pancreatitis,AP)患者病情嚴(yán)重程度及預(yù)后的相關(guān)性。方法收集2012年1月至2015年9月期間本科466例AP患者資料,按血清TG值是否高于1.70 mmol/L分為正常組與升高組,升高組再分為輕、中、重組,比較病情嚴(yán)重程度及預(yù)后有無差異,以是否合并全身炎癥反應(yīng)綜合征(systemic inflammatory response syndrome,SIRS)為因變量,進(jìn)行Logistic回歸分析。比較重度血脂升高組血液凈化治療前后指標(biāo)。結(jié)果 466例AP患者中血脂升高組271例(58.2%),血脂正常組195例(41.8%),血脂升高組SIRS(42.8%vs23.6%,P0.01)、胸腔積液(55.0%vs 43.1%,P0.05)、病情程度(30.6%vs 19.5%,P0.01)明顯高于正常組;組間器官功能障礙(13.7%vs 13.8%)差異無統(tǒng)計(jì)學(xué)意義(P0.05);隨著TG升高,各組并發(fā)SIRS風(fēng)險(xiǎn)越高(P0.01)。Logistic回歸分析TG與SIRS獨(dú)立相關(guān)(OR=1.157,95%CI:1.102~1.215,P0.01)。重度血脂升高組中使用血液凈化(29例)治療后,TG水平、白細(xì)胞計(jì)數(shù)、APACHEⅡ評分與治療前比較明顯降低(P0.01)。結(jié)論 TG升高的AP患者預(yù)后更差,血清TG水平越高,SIRS發(fā)生率越高,但合并器官功能障礙無差異。血液凈化能有效緩解血脂重度升高患者的病情。
[Abstract]:Objective to investigate the relationship between serum triglyceride (TG) level and severity and prognosis of patients with acute pancreatitis (AP). Methods data of 466 AP patients from January 2012 to September 2015 were collected and divided into normal group and elevated group according to whether the serum TG value was higher than 1.70 mmol/L. The elevated group was subdivided into mild, moderate and recombined group, and the severity and prognosis of AP were compared. Logistic regression analysis was performed to determine whether (systemic inflammatory response syndrome was associated with systemic inflammatory response syndrome (Sirs) as dependent variable. To compare the indexes before and after blood purification treatment in patients with severe hyperlipidemia. Results among 466 AP patients, 271 cases (58.2%) were in hyperlipidemia group, 195 cases (41.8%) in normal blood lipid group, SIRS (42.8 vs 23.6P0.01), pleural effusion (55.0%vs 43.1%, P0.05) and degree of illness (30.6%vs 19.5C) in AP group, but there was no significant difference in 13.7%vs 13.8% between groups (P0.05). The higher the risk of SIRS in each group was (P0.01). Logistic regression analysis showed that TG was independently correlated with SIRS (OR 1.15795 CI: 1.102 鹵1.215P0.01). In the hyperlipidemia group (29 cases), the level of TG, white blood cell count and Apache 鈪，

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