配對血漿濾過吸附聯合高容量血液濾過治療老年重癥胰腺炎的療效及對炎癥因子的影響
發(fā)布時間:2018-08-09 11:59
【摘要】:目的探討配對血漿濾過吸附(CPFA)聯合高容量血液濾過(HVHF)治療老年急性重癥胰腺炎(SAP)的療效及其對炎癥因子的影響。方法選擇該院2012年1月至2014年1月收治的60例老年SAP患者,按隨機數字表法平均分為兩組各30例,研究組給予CPFA聯合HVHF治療,對照組僅給予HVHF治療,比較兩組患者治療前和治療7 d后急性生理及慢性健康狀況(APACHE)Ⅱ評分及平均動脈壓(MAP)、心率(HR)、血氧飽和度(Sp O2)等指標變化、血漿白細胞介素(IL)-6、IL-8、IL-10、腫瘤壞死因子(TNF)-α及C反應蛋白(CRP)、白細胞計數(WBC)等水平以及住院時間和治療過程中不良反應情況。結果研究組治療7 d后APACHEⅡ評分較治療前明顯降低,且低于對照組(P0.05);研究組治療后MAP、HR及Sp O2水平較治療前明顯改善,且改善程度明顯優(yōu)于對照組(均P0.05);研究組治療后血漿IL-6、IL-8、IL-10、TNF-α、CPR及WBC水平較治療前明顯改善,且改善程度均明顯優(yōu)于對照組(均P0.05);研究組住院時間短于對照組(P0.05);兩組患者治療過程中均未出現凝血、膜過敏、栓塞及血小板減少等不良反應。結論 CPFA聯合HVHF治療SPA療效顯著,可有效改善患者炎癥因子水平,縮短住院時間,安全可靠,值得臨床推廣應用。
[Abstract]:Objective to investigate the effect of paired plasma filtration adsorption (CPFA) combined with high volume hemofiltration (HVHF) on elderly patients with severe acute pancreatitis (SAP) and its effect on inflammatory factors. Methods from January 2012 to January 2014, 60 elderly patients with SAP were randomly divided into two groups: 30 cases in each group. The study group was treated with CPFA combined with HVHF, while the control group was treated with HVHF only. The changes of (APACHE) 鈪,
本文編號:2174007
[Abstract]:Objective to investigate the effect of paired plasma filtration adsorption (CPFA) combined with high volume hemofiltration (HVHF) on elderly patients with severe acute pancreatitis (SAP) and its effect on inflammatory factors. Methods from January 2012 to January 2014, 60 elderly patients with SAP were randomly divided into two groups: 30 cases in each group. The study group was treated with CPFA combined with HVHF, while the control group was treated with HVHF only. The changes of (APACHE) 鈪,
本文編號:2174007
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