【摘要】：目的:研究通腑清胰方輔助治療重癥急性胰腺炎(SAP)的療效,并且探討其對(duì)腸道黏膜屏障功能和免疫功能的影響。方法:2012年1月~2013年12月在浙江省富陽(yáng)市人民醫(yī)院就診的112例SAP患者按隨機(jī)數(shù)字表分為觀察組和對(duì)照組,每組各56例。對(duì)照組患者接受常規(guī)治療,觀察組患者在常規(guī)治療的基礎(chǔ)上加服通腑清胰方,兩組療程均為14天。于治療前及治療14天對(duì)兩組患者腸道黏膜屏障功能和免疫功能進(jìn)行評(píng)估,比較兩組患者治療后腸麻痹恢復(fù)時(shí)間和APACHEⅡ評(píng)分,并對(duì)兩組患者的臨床療效進(jìn)行評(píng)價(jià)。結(jié)果:(1)治療后觀察組患者的腹痛緩解時(shí)間、腹脹緩解時(shí)間、腸鳴音恢復(fù)時(shí)間和首次排便時(shí)間均較對(duì)照組顯著縮短(P0.01);(2)治療后兩組患者APACHEⅡ評(píng)分均較治療前顯著降低(P0.01),且治療后7、14天時(shí)觀察組患者APACHEⅡ評(píng)分顯著低于對(duì)照組(P0.01);(3)治療14天時(shí)觀察組患者血清內(nèi)毒素、D-乳酸、二胺氧化酶、淀粉酶水平均較對(duì)照組顯著降低(P0.01);(4)治療14天時(shí)觀察組患者CD4+、CD4+/CD8+和Treg細(xì)胞較對(duì)照組患者顯著升高(P0.01),CD8+較對(duì)照組患者顯著降低(P0.01);(5)觀察組患者的總有效率顯著高于對(duì)照組(P0.05)。結(jié)論:通腑清胰方輔助治療重癥急性胰腺炎有較好的療效,可改善重癥急性胰腺炎患者腸道黏膜屏障功能和免疫功能。
[Abstract]:Aim: to study the effect of Tongfu Qingyi recipe (Tongfu Qingyi recipe) on (SAP) in severe acute pancreatitis (SAP) and its effect on intestinal mucosal barrier function and immune function. Methods: from January 2012 to December 2013, 112 SAP patients in Fuyang people's Hospital of Zhejiang Province were randomly divided into observation group (n = 56) and control group (n = 56). The patients in the control group were treated with routine therapy, and the patients in the observation group were treated with Tongfu Qingyi recipe on the basis of routine treatment. The course of treatment in both groups was 14 days. The intestinal mucosal barrier function and immune function were evaluated before and 14 days after treatment. The recovery time and APACHE 鈪，

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