發(fā)布時間：2018-08-07 17:18

【摘要】：目的探討血清脂肪細(xì)胞因子與2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者下肢動脈粥樣硬化的相關(guān)性。方法記錄176例T2DM合并NAFLD患者入院后的一般臨床資料,檢測入院時血清脂聯(lián)素、瘦素、白細(xì)胞介素(IL)-6且均接受彩色多普勒超聲檢測下肢動脈,按照動脈內(nèi)-中膜厚度(IMT)及踝臂指數(shù)(ABI)分為Ⅰ組(IMT1 mm,n=42)、Ⅱ組(1 mm≤IMT≤1.2 mm,n=55)、Ⅲ組(IMT1.2 mm,n=79);ABI1.3組(n=64)、0.9~1.3組(n=76)及0.9組(n=36);同期另選50例體檢健康者為對照組。結(jié)果Ⅰ組、Ⅱ組、Ⅲ組、對照組體質(zhì)指數(shù)(BMI)、舒張壓(DBP)、空腹血糖(FPG)、2 h餐后血糖(2 h PG)、糖化血紅蛋白(Hb A1c)、甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)存在統(tǒng)計學(xué)差異(P0.05),Ⅲ組BMI、DBP高于對照組;Ⅲ組FPG、2 h PG、Hb A1c、LDL-C高于Ⅱ組、Ⅰ組及對照組(P0.05);Ⅲ組TG、TC亦高于Ⅰ組及對照組(P0.05);四組血清脂聯(lián)素、瘦素、IL-6亦存在顯著差異(P0.05),血清瘦素、IL-6水平從對照組到Ⅲ組逐漸增高(P0.05),而血清脂聯(lián)素則逐漸降低(P0.05);ABI1.3組、ABI 0.9~1.3組及ABI0.9組血清瘦素、IL-6水平逐漸增高(P0.05),血清脂聯(lián)素則逐漸降低(P0.05);IMT及ABI分別與瘦素、IL-6呈現(xiàn)正相關(guān),而與脂聯(lián)素呈負(fù)相關(guān);多元逐步回歸分析提示:血清瘦素、IL-6與IMT呈獨立正相關(guān)(P0.05),而脂聯(lián)素則與其呈獨立負(fù)相關(guān)(P0.05);多因素非條件Logistic回歸分析提示:血清瘦素、IL-6是發(fā)生ABI0.9的高危因素,而脂聯(lián)素則是其保護(hù)因素。結(jié)論血清高水平瘦素、IL-6與T2DM合并NAFLD患者下肢動脈粥樣硬化的形成及發(fā)展密切相關(guān),脂聯(lián)素則可能抗炎抑制粥樣硬化形成,從而延緩下肢動脈粥樣硬化性疾病的發(fā)生。
[Abstract]:Objective to investigate the relationship between serum adipocyte factors and lower extremity atherosclerosis in patients with type 2 diabetes mellitus (T2DM) and non alcoholic fatty liver (NAFLD). Methods the general clinical data of 176 patients with T2DM complicated with NAFLD were recorded. Serum adiponectin, leptin and interleukin (IL) -6 were detected on admission. The arteries of lower extremity were detected by color Doppler ultrasound. According to intima-media thickness (IMT) and malleolus brachial index (ABI), (IMT) was divided into three groups: group 鈪，

本文編號：2170778