【摘要】：目的:探討難治性炎癥性腸病(Refractory inflammatory bowel disease)患者艱難梭狀芽抱桿菌感染(Clostridium difficile infection,CDI)的臨床特征,為臨床防治艱難梭狀芽孢桿菌感染提供依據(jù)。方法:連續(xù)性收集2013年1月至2016年1月醫(yī)院收治的活動期難治性炎癥性腸病患者92例和緩解期難治性炎癥性腸病21例,采用熒光酶免疫法檢測其糞便中艱難梭狀芽孢桿菌感染的情況,分析艱難梭狀芽孢桿菌感染的難治性炎癥性腸病患者的臨床特征。結(jié)果:19例活動期難治性炎癥性腸病患者感染艱難梭狀芽孢桿菌,感染率為20.65%,其中潰瘍性結(jié)腸炎患者感染率為20.83%,克羅恩病患者感染率為20.45%。使用抗菌藥物、萬古霉素和處于活動期的難治性炎癥性腸病患者艱難梭狀芽孢桿菌感染率顯著增高(P0.05)。潰瘍性結(jié)腸炎患者病情嚴(yán)重度為重度、中度和輕度的患者艱難梭狀芽孢桿菌感染率分別為44.44%、5.56%和8.33%,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)腸受累的患者艱難梭狀芽孢桿菌感染率顯著升高(P0.05)�？肆_恩病結(jié)腸部位受累的患者艱難梭狀芽孢桿菌感染率顯著升高(P0.05)。結(jié)論:難治性炎癥性腸病患者艱難梭狀芽孢桿菌感染率較高,與抗菌藥物、萬古霉素、病情活動度、病情嚴(yán)重度和結(jié)腸受累有關(guān)。
[Abstract]:Objective: to investigate the clinical features of Clostridium diffracta infection (Clostridium difficile) in patients with refractory inflammatory bowel disease (Refractory inflammatory bowel disease), and to provide a basis for clinical prevention and treatment of Clostridium diffculent infection. Methods: from January 2013 to January 2016, 92 patients with active refractory inflammatory bowel disease and 21 patients with remission refractory inflammatory bowel disease were collected. Fluorescent enzyme immunoassay was used to detect the infection of Clostridium diffracta in feces and to analyze the clinical features of the patients with refractory inflammatory bowel disease. Results the infection rate was 20.65 in 19 patients with active refractory inflammatory bowel disease. The infection rate was 20.83 in ulcerative colitis and 20.45in Crohn's disease. The infection rate of Clostridium difficulty in patients with antibiotic, vancomycin and active refractory inflammatory bowel disease was significantly increased (P0.05). The severity of ulcerative colitis was severe and the infection rate of moderate and mild patients was 44.445.56% and 8.33 respectively. The difference was statistically significant (P0.05). The infection rate of Clostridium difficulty was significantly increased in patients with colon involvement (P0.05). The infection rate of Clostridium difficulty in patients with Crohn's disease was significantly higher than that in patients with colon involvement (P0.05). Conclusion: the infection rate of Clostridium difficulty in patients with refractory inflammatory bowel disease is high, which is related to antibiotics, vancomycin, disease activity, severity of disease and colonic involvement.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R574

【參考文獻(xiàn)】

相關(guān)期刊論文 前8條

1 Orna Nitzan;Mazen Elias;Avi Peretz;Walid Saliba;;Role of antibiotics for treatment of inflammatory bowel disease[J];World Journal of Gastroenterology;2016年03期

2 陳康部;張金平;;艱難梭菌相關(guān)性腸炎的治療進(jìn)展[J];醫(yī)學(xué)綜述;2013年03期

3 ;炎癥性腸病診斷與治療的共識意見(2012年·廣州)[J];胃腸病學(xué);2012年12期

4 袁媛;;護(hù)理干預(yù)對炎癥性腸病患者生存質(zhì)量的影響[J];實用臨床醫(yī)藥雜志;2011年20期

5 王浦;陳燁;姜泊;;艱難梭菌感染的流行病學(xué)研究進(jìn)展[J];國際消化病雜志;2011年04期

6 劉黎黎;王吉耀;;艱難梭菌相關(guān)性腹瀉的治療進(jìn)展[J];中國臨床醫(yī)學(xué);2010年01期

7 秦臻;張?zhí)┎?;偽膜性腸炎的藥物治療方案與評價[J];中國醫(yī)院用藥評價與分析;2006年03期

8 黃德旺,肖冰;偽膜性腸炎42例臨床分析[J];中國中西醫(yī)結(jié)合消化雜志;2001年05期

，

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