不同程度肝損傷患者紅細(xì)胞分布寬度與凝血酶原時(shí)間的差異
發(fā)布時(shí)間：2018-07-17 05:12
【摘要】：目的探討不同程度肝損傷患者紅細(xì)胞分布寬度(RDW)與凝血酶原時(shí)間(PT)的變化趨勢(shì)及其臨床意義。方法選取重慶醫(yī)科大學(xué)附屬第二醫(yī)院2014年1月至2015年6月住院乙型肝炎患者100例(乙肝組),乙型肝炎肝硬化患者100例(肝硬化組),乙型肝炎病毒相關(guān)的原發(fā)性肝細(xì)胞癌患者50例(肝癌組),以及同期健康體檢者100例(對(duì)照組)。采用Sysmex XE-2100全自動(dòng)血細(xì)胞分析儀檢測(cè)所有受試者外周血RDW與紅細(xì)胞平均體積(MCV),采用Stago Rack Evolutio全自動(dòng)凝血儀檢測(cè)PT,并進(jìn)行比較分析。結(jié)果除肝硬化組與肝癌組RDW比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.099),其余各組間比較差異均有統(tǒng)計(jì)學(xué)意義(P0.01),隨著病情加重,RDW逐漸變寬;各組間MCV比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);除乙肝組與肝硬化組PT比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.234),其余各組間比較差異均有統(tǒng)計(jì)學(xué)意義(P0.01),隨著病情加重,PT逐漸延長(zhǎng)。結(jié)論RDW、PT的增加與肝損傷的嚴(yán)重程度相關(guān),RDW可能成為預(yù)測(cè)患者肝損傷程度的指標(biāo)。
[Abstract]:Objective to investigate the changes of erythrocyte distribution width (RDW) and prothrombin time (PT) in patients with liver injury and their clinical significance. Methods from January 2014 to June 2015, 100 patients with hepatitis B (hepatitis B group), 100 patients with hepatitis B cirrhosis (cirrhosis group) and 100 patients with hepatitis B virus related primary liver were selected from the second affiliated Hospital of Chongqing Medical University. There were 50 cases of cell carcinoma (liver cancer group) and 100 cases of health examination (control group). The RDW and mean erythrocyte volume (MCV) in peripheral blood of all subjects were detected by Sysmex XE-2100 automatic blood cell analyzer and PTT was detected by Stago Rack Evolutio automatic coagulation instrument. Results there was no significant difference in RDW between liver cirrhosis group and liver cancer group (P0.099), but there was significant difference between the other groups (P0.01). The difference was not statistically significant (P0.05); except hepatitis B group and liver cirrhosis group PT, the difference was not statistically significant (P0. 234), the other groups were statistically significant (P0.01), with the severity of the disease gradually prolonged PT. Conclusion the increase of RDW PT is related to the severity of liver injury. RDW may be a predictor of liver injury in patients.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第二醫(yī)院檢驗(yàn)科;重慶市中醫(yī)院骨科;
【基金】：重慶市衛(wèi)生局項(xiàng)目資助(2012-2-60)
【分類(lèi)號(hào)】：R512.62;R575;R735.7
[Abstract]:Objective to investigate the changes of erythrocyte distribution width (RDW) and prothrombin time (PT) in patients with liver injury and their clinical significance. Methods from January 2014 to June 2015, 100 patients with hepatitis B (hepatitis B group), 100 patients with hepatitis B cirrhosis (cirrhosis group) and 100 patients with hepatitis B virus related primary liver were selected from the second affiliated Hospital of Chongqing Medical University. There were 50 cases of cell carcinoma (liver cancer group) and 100 cases of health examination (control group). The RDW and mean erythrocyte volume (MCV) in peripheral blood of all subjects were detected by Sysmex XE-2100 automatic blood cell analyzer and PTT was detected by Stago Rack Evolutio automatic coagulation instrument. Results there was no significant difference in RDW between liver cirrhosis group and liver cancer group (P0.099), but there was significant difference between the other groups (P0.01). The difference was not statistically significant (P0.05); except hepatitis B group and liver cirrhosis group PT, the difference was not statistically significant (P0. 234), the other groups were statistically significant (P0.01), with the severity of the disease gradually prolonged PT. Conclusion the increase of RDW PT is related to the severity of liver injury. RDW may be a predictor of liver injury in patients.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第二醫(yī)院檢驗(yàn)科;重慶市中醫(yī)院骨科;
【基金】：重慶市衛(wèi)生局項(xiàng)目資助(2012-2-60)
【分類(lèi)號(hào)】：R512.62;R575;R735.7
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