【摘要】：目的觀察低聚果糖(FOS)對(duì)小鼠腸道黏膜的影響,并探討其對(duì)結(jié)腸炎的治療作用及可能機(jī)制。方法用5%DSS誘導(dǎo)建立小鼠結(jié)腸炎模型,將30例小鼠隨機(jī)分成正常組、模型組、FOS組。FOS組在模型建立后飲用配置好的5%FOS溶液。觀察各組疾病活動(dòng)指數(shù)(DAI),實(shí)驗(yàn)結(jié)束后觀察結(jié)腸長(zhǎng)度變化、組織學(xué)損傷評(píng)分、菌群計(jì)數(shù)統(tǒng)計(jì)以及IL-6、IL-33、TNF-α、RegⅢγ的表達(dá)。結(jié)果 FOS組DAI(P0.000 1)及組織學(xué)損傷評(píng)分(P0.000 1)明顯低于模型組,模型組小鼠結(jié)腸質(zhì)地變硬且黏膜皺褶消失(P0.01),FOS組結(jié)腸致病菌與模型組相比顯著減少(P0.01),FOS組結(jié)腸IL-6(P0.05)、IL-33(P0.05)的表達(dá)量相比于模型組顯著降低,TNF-α(P0.05)、RegⅢγ(P0.05)雖有降低但無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論低聚果糖能夠改善結(jié)腸炎小鼠有益菌群的比例,降低促炎細(xì)胞因子IL-33及IL-6的水平,減輕腸道炎癥反應(yīng)。
[Abstract]:Objective to observe the effect of fructooligosaccharide (FOS) on intestinal mucosa in mice and to explore the therapeutic effect and possible mechanism of FOS on colitis. Methods the colitis model of mice was induced by 5 DSS. 30 mice were randomly divided into normal group and FOS group. The FOS group drank the 5 FOS solution after the model was established. Disease activity index (Dai), colonic length, histological injury score, microflora count and the expression of IL-6 and IL-3TNF- 偽 TNF- 偽 Reg 鈪，

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