發(fā)布時(shí)間：2018-07-11 17:45

  本文選題：彈性成像技術(shù) + 肝硬化��； 參考：《第二軍醫(yī)大學(xué)學(xué)報(bào)》2015年09期

【摘要】：目的比較實(shí)時(shí)組織彈性(real-time tissue elastography,RTE)技術(shù)、血清學(xué)檢驗(yàn)診斷肝硬化的診斷價(jià)值,探討臨床非侵入性診斷肝硬化的優(yōu)效方法。方法回顧性分析我院行肝切除手術(shù)或肝穿刺活檢術(shù)住院患者的臨床資料(n=124),收集病理學(xué)結(jié)果、RTE檢查和血清學(xué)檢驗(yàn)資料。RTE用肝纖維化指數(shù)(LFI)表示;血清學(xué)檢驗(yàn)分為直接指標(biāo)和間接指標(biāo),直接指標(biāo)為肝臟纖維化四項(xiàng)(肝纖四項(xiàng)),包括透明質(zhì)酸(HA)、層粘連蛋白(LN)、Ⅲ型前膠原(PCⅢ)、Ⅳ型膠原(Ⅳ-C);間接指標(biāo)為天冬氨酸轉(zhuǎn)氨酶與血小板計(jì)數(shù)的比值(AST-to-platelet ratio index,APRI)。以病理診斷為金標(biāo)準(zhǔn),繪制ROC曲線比較RTE和血清指標(biāo)對(duì)肝硬化的診斷效能。結(jié)果 124例患者中非肝硬化組93例(75.0%),肝硬化組31例(25.0%)。以病理結(jié)果作為金標(biāo)準(zhǔn),HA的診斷敏感度為67.7%,特異度為62.4%,準(zhǔn)確度為63.7%;APRI指數(shù)的診斷敏感度為80.6%,特異度為49.5%,準(zhǔn)確度為58.3%;LFI的診斷敏感度為93.5%,特異度為71.0%,準(zhǔn)確度為76.6%。結(jié)論 LFI、HA、APRI指數(shù)對(duì)肝硬化均具有診斷價(jià)值,其中RTE測定的LFI診斷效能最高,APRI指數(shù)具有較高的敏感度但特異度最低。
[Abstract]:Objective to compare the diagnostic value of real-time tissue elastography (RTE) technique with serological examination in the diagnosis of liver cirrhosis and to explore the effective method of clinical non-invasive diagnosis of cirrhosis. Methods the clinical data of inpatients undergoing hepatectomy or biopsy were analyzed retrospectively. The pathological results and serological data were collected. The RTE was expressed by the liver fibrosis index (LFI). Serological tests are divided into direct and indirect indicators, The direct indexes were liver fibrosis (HA), laminin (LN), procollagen 鈪，

本文編號(hào)：2116082