本文選題：肝硬化 + 膽汁淤積��； 參考：《重慶醫(yī)學(xué)》2015年26期

【摘要】：目的研究S-腺苷蛋氨酸(SAMe)對奈乙硫氰酸酯(ANIT)誘發(fā)大鼠藥物型膽汁淤積性肝病肝纖維化的保護(hù)作用。方法將18只SD大鼠分為3組:A組(空白對照組)、B組(造模+NS)、C組(造模+SAMe),每組各6只,各組大鼠腹腔注射后72h處理。采用全自動生化分析儀檢測各組肝臟血清學(xué)指標(biāo),并取肝臟組織行HE染色及MASSON染色觀察肝臟病理組織學(xué)變化及膠原含量改變。結(jié)果 C組大鼠的血清學(xué)指標(biāo)谷氨酸氨基轉(zhuǎn)移酶(ALT)、天冬氨酸氨基轉(zhuǎn)移酶(AST)、總膽紅素(TBiL)、直接膽紅素(DBiL)、間接膽紅素(IBiL)、谷胺酰轉(zhuǎn)肽酶(γ-GGT)、堿性磷酸酶(ALP)、總膽汁酸(TBA)明顯低于B組,3組之間比較差異均有統(tǒng)計學(xué)意義(P0.05);但3組之間總膽固醇(Chol)水平差異無統(tǒng)計學(xué)意義(P0.05)。C組大鼠的膠原纖維含量及膠原纖維面積比均明顯低于B組,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論 SAMe能通過改善藥物型膽汁淤積性肝病的肝功能,降低膠原纖維含量及面積,進(jìn)一步保護(hù)肝臟組織。
[Abstract]:Objective to study the protective effect of S-adenosylmethionine (SAMe) on hepatic fibrosis induced by neethylthiocyanate (ANIT) in rats with drug-induced cholestatic liver disease. Methods Eighteen Sprague-Dawley rats were divided into 3 groups: group A (blank control group), group B (model NS) and group C (model SAMe), 6 rats in each group. The rats in each group were treated 72 hours after intraperitoneal injection. The liver serological indexes were detected by automatic biochemical analyzer, and liver tissues were stained by HE staining and MASson staining to observe the changes of liver histopathology and collagen content. Results the serum levels of glutamic acid aminotransferase (alt), aspartate aminotransferase (AST), total bilirubin (TBiL), direct bilirubin (DBiL), indirect bilirubin (IBiL), glutamyl transpeptidase (緯 -GGT), alkaline phosphatase (ALP), total bile acid (TBA) were significantly lower in group C rats. There were significant differences between the three groups (P0.05), but there was no significant difference in the level of total cholesterol (Chol) between the three groups (P0.05). The content of collagen fibers and the area ratio of collagen fibers in group C were significantly lower than those in group B (P0.05). The difference was statistically significant (P0.05). Conclusion SAMe can further protect liver tissue by improving liver function, reducing the content and area of collagen fibers in patients with drug-induced cholestatic liver disease.
【作者單位】： 南方醫(yī)科大學(xué)附屬珠江醫(yī)院消化內(nèi)科;
【分類號】：R575

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 張釗;龔建平;;S-腺苷蛋氨酸對內(nèi)毒素性肝損害的保護(hù)作用[J];第三軍醫(yī)大學(xué)學(xué)報;2010年11期

2 朱超慧;李楠;吳凱;王雪明;張林;翟俊山;王艷梅;;藥物性肝損害S-腺苷蛋氨酸治療的臨床分析[J];臨床肝膽病雜志;2010年06期

3 禹錚;賈繼東;;藥物性肝損害的危險因素、診斷規(guī)范及停藥標(biāo)準(zhǔn)[J];臨床肝膽病雜志;2013年09期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 姚飛;汪燕燕;;綜合分析藥物性肝損傷9355例[J];安徽醫(yī)藥;2011年10期

2 倪鴻昌;凌芳;;103例藥物性肝損傷分析[J];安徽醫(yī)藥;2012年03期

3 劉釗;王金環(huán);于紅衛(wèi);李娟;孟慶華;;50例藥物性肝損傷的臨床病理特點(diǎn)分析[J];北京醫(yī)學(xué);2011年06期

4 計一平,胡晉紅,劉濤,張順民,蔡溱,劉厚佳,龔瀟峗;阿魏酸鈉對小鼠急性肝損傷的保護(hù)作用[J];第二軍醫(yī)大學(xué)學(xué)報;2000年10期

5 潘雪飛;杜斌;范群;陳小鳳;張長法;;綜合分析藥物性肝損傷4076例[J];東南國防醫(yī)藥;2009年06期

6 劉釗;李宏軍;于紅衛(wèi);李娟;孟慶華;;藥物性肝病的CT表現(xiàn)與病理對照[J];放射學(xué)實(shí)踐;2011年01期

7 王玉華,洪振豐;抗肝炎中藥的實(shí)驗研究進(jìn)展[J];福建中醫(yī)學(xué)院學(xué)報;2002年04期

8 黃立峰;盧若艷;;金線蓮提取物對CCl_4所致小鼠急性肝損傷的保護(hù)作用[J];福州總醫(yī)院學(xué)報;2005年Z1期

9 張琪;彭R，

本文編號：2100473