本文選題：胎血 + 臍血干細(xì)胞移植��； 參考：《中國全科醫(yī)學(xué)》2015年02期

【摘要】：目的探討臍血干細(xì)胞聯(lián)合人參促分化合劑治療失代償期肝硬化的療效。方法選擇2012年2月—2013年4月衡水市哈勵遜國際和平醫(yī)院消化內(nèi)科確診的失代償期肝硬化患者30例,術(shù)前行常規(guī)保肝治療,采用細(xì)胞分離技術(shù)從臍帶血中提取干細(xì)胞,經(jīng)肝固有動脈將干細(xì)胞懸液移植入肝臟。移植成功后給予人參促分化合劑輔助治療,治療14 d。治療后第16周觀察患者肝功能指標(biāo),包括ALT、AST、清蛋白(Alb)、總膽紅素(TBi L)、凝血酶原活動度(PTA);治療后第24周觀察血清學(xué)纖維化指標(biāo),包括透明質(zhì)酸(HA)、層粘連蛋白(LN)、Ⅲ型前膠原(PC-Ⅲ)、Ⅳ型膠原(Ⅳ-C);治療后第24周行CT檢查,觀察肝臟影像學(xué)變化,包括肝臟最大截面積和肝臟平掃CT值。結(jié)果治療后第16周,患者血漿ALT、AST、TBi L低于治療前,Alb、PTA高于治療前(P0.05)。治療后第24周,患者HA、PC-Ⅲ、Ⅳ-C、LN均低于治療前(P0.05)。治療后第24周,患者肝臟最大截面積多于治療前(P0.05);治療前后,肝臟平掃CT值比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論臍血干細(xì)胞聯(lián)合人參促分化合劑可以改善失代償期肝硬化患者肝功能,修復(fù)肝臟損傷,是臨床治療失代償期肝硬化的一種有效措施。
[Abstract]:Objective to investigate the therapeutic effect of cord blood stem cells combined with ginseng promoting differentiation mixture in the treatment of decompensated cirrhosis. Methods from February 2012 to April 2013, 30 patients with decompensated cirrhosis diagnosed by Department of Digestive Medicine, Hallieson International Peace Hospital, Hengshui City, were treated with routine hepatoprotective therapy. Stem cells were extracted from umbilical cord blood by cell separation technique. Stem cell suspension was transplanted into the liver via the proper hepatic artery. After successful transplantation, ginseng promoting differentiation mixture was given adjuvant treatment for 14 days. The indexes of liver function including alt AST, total bilirubin (TBiL) and prothrombin activity (PTA) of serum albumin (Alb), were observed at the 16th week after treatment, and the serum fibrosis indexes were observed at the 24th week after treatment. Hyaluronic acid (HA), laminin (LN), procollagen 鈪，

本文編號：2075927