本文選題：消化性潰瘍 + 非甾體抗炎藥　； 參考：《中國(guó)輸血雜志》2017年05期

【摘要】：目的探討血漿輸注對(duì)非甾體抗炎藥(NSAIDs)相關(guān)性消化性潰瘍并出血的臨床轉(zhuǎn)歸影響。方法收集本院NSAIDs相關(guān)性消化性潰瘍并出血病例97例,根據(jù)是否曾輸注血漿分為實(shí)驗(yàn)組:56例輸注紅細(xì)胞和血漿;對(duì)照組:41例僅輸注紅細(xì)胞;分析2組病例的一般臨床資料、輸血量、輸血后療效、臨床轉(zhuǎn)歸相關(guān)指標(biāo)。結(jié)果實(shí)驗(yàn)組與對(duì)照組比較:1)2組的性別、年齡、休克發(fā)生率、潰瘍大小、潰瘍Forrest分級(jí)、合并癥、輸血后Hb等無(wú)明顯差異(P0.05);2)PT、APTT(s)在輸血前分別為20.30±2.65 vs 19.76±2.07(P0.05)、49.70±2.93 vs 46.93±5.10(P0.05),在輸血后分別為13.12±1.68 vs 18.13±1.80(P0.05)、31.67±5.06 vs 40.41±2.64(P0.05);實(shí)驗(yàn)組輸血前、后凝血功能差異明顯(P0.05),而對(duì)照組變化基數(shù)(P0.05);3)平均紅細(xì)胞輸注量(m L)分別為420±63.75 vs 673±55.62(P0.05),好轉(zhuǎn)率分別為91.0%(51/56)vs 73.2%(30/41)(P0.05),平均住院時(shí)間(d)分別為6.37±2.15 vs11.21±3.07(P0.05),再出血率分別為5.4%vs 19.5%(P0.05)。結(jié)論早期輸注血漿既可及時(shí)糾正NSAIDs相關(guān)性消化性潰瘍并出血患者凝血功能,又能有效減少患者紅細(xì)胞輸注用量,縮短患者平均住院時(shí)間,有助于更好的臨床轉(zhuǎn)歸預(yù)后。
[Abstract]:Objective to investigate the effect of plasma infusion on the clinical outcome of non-steroidal anti-inflammatory drugs (NSAIDs)-associated peptic ulcer and hemorrhage. Methods 97 cases of NSAIDs associated peptic ulcer with bleeding were collected and divided into experimental group (n = 56) and control group (n = 41). The quantity of blood transfusion, the curative effect after blood transfusion, and the related indexes of clinical outcome. Results the sex, age, incidence of shock, ulcer size, ulcers Forrest grade and complications were compared between the experimental group and the control group. After blood transfusion, there was no significant difference in HB (20.30 鹵2.65 vs 19.76 鹵2.07 vs 49.70 鹵2.93 vs 46.93 鹵5.10 P0.05) before blood transfusion, 13.12 鹵1.68 vs 18.13 鹵1.80 P0.05V before blood transfusion vs 31.67 鹵5.06 vs 40.41 鹵2.64P0.05in the experimental group, respectively. The difference of blood coagulation function was significant (P 0.05), while the mean RBC infusion volume of the control group was 420 鹵63.75 vs 673 鹵55.62% P0.05L, respectively. The improvement rate was 91.0%(51/56)vs 73.2% 30% P 0.05, the average hospitalization time was 6.37 鹵2.15 vs11.21 鹵3.07 vs11.21 P 0.05L, and the rate of rebleeding was 5.4%vs 19.5T P 0.05U, and the average hospitalization time was 6.37 鹵2.15 vs11.21 鹵3.07g / P0.05a, respectively, and the average time of hospitalization was 6.37 鹵2.15 vs11.21 鹵3.07g / P0.05g / L, respectively, and the average time of hospitalization was 6.37 鹵2.15 vs11.21 鹵3.07g / P0.05a, respectively. Conclusion early infusion of plasma can not only correct the coagulation function of patients with NSAIDs associated peptic ulcer and bleeding, but also reduce the amount of erythrocyte transfusion and shorten the average hospitalization time of patients, which is helpful to the prognosis of patients with NSAIDs associated peptic ulcer.
【作者單位】： 南昌大學(xué)第一附屬醫(yī)院輸血科;
【基金】：江西省科技重大項(xiàng)目(20144BBG70001)
【分類號(hào)】：R457.1;R573.1

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本文編號(hào)：2014282