脂肪肝相關(guān)危險因素的評估
本文選題:脂肪肝 + 危險因素; 參考:《福建醫(yī)科大學(xué)》2014年碩士論文
【摘要】:目的 探討脂肪肝發(fā)病的相關(guān)危險因素。 方法 選取2013.9-11月具有完整資料的福建省立醫(yī)院體檢中心的健康體檢者1000例,排除惡性腫瘤、病毒性肝炎標(biāo)志物陽性、慢性胰腺炎、嚴(yán)重腎功損傷、急性感染或創(chuàng)傷、長期激素應(yīng)用史,通過問卷調(diào)查、體格檢查、實驗室檢測及腹部超聲檢查對脂肪肝組的年齡、性別、體重指數(shù)、血壓、血糖、血脂、血尿酸、肝功能、血常規(guī)及有無膽石癥與非脂肪肝組進行對比分析。 結(jié)果 1000例體檢者中,,超聲診斷出脂肪肝416例(41.6%),其中男性287例(51.9%),女性129例(28.9%),二者檢出率間差異有統(tǒng)計學(xué)意義(χ=54.011,P0.05);脂肪肝組超重、肥胖、糖代謝紊亂、高血壓、血脂異常、高尿酸血癥的患病率高于非脂肪肝組,差異有統(tǒng)計學(xué)意義(P0.05)。單因素分析顯示,脂肪肝組體重指數(shù)、收縮壓、舒張壓、甘油三酯、總膽固醇、低密度脂蛋白、空腹血糖、尿酸等均高于非脂肪肝組,差異有統(tǒng)計學(xué)意義(P0.05),而高密度脂蛋白膽固醇則低于非脂肪肝組,差異亦有統(tǒng)計學(xué)意義(P0.05)。多因素Logistic回歸結(jié)果顯示年齡、性別(男性)、體重指數(shù)、甘油三酯、低密度脂蛋白、空腹血糖6項指標(biāo)進入了回歸方程(P0.05)。 結(jié)論 超重、肥胖、高血壓、糖代謝紊亂、血脂異常、高尿酸血癥都增加了脂肪肝的患病風(fēng)險。年齡、性別、體重指數(shù)、甘油三酯、低密度脂蛋白、空腹血糖是脂肪肝發(fā)病的危險因素。
[Abstract]:Objective to investigate the risk factors of fatty liver disease. Methods 1000 healthy persons from Fujian Provincial Hospital physical examination Center from September to November 2013.were selected to exclude malignant tumor, positive markers of viral hepatitis and chronic pancreatitis. Severe renal injury, acute infection or trauma, long history of hormone use, age, sex, body mass index, blood pressure, blood glucose, blood lipid, serum uric acid in fatty liver group by questionnaire, physical examination, laboratory and abdominal ultrasound, The liver function, blood routine, cholelithiasis and non-fatty liver were compared and analyzed. There were 41.6 cases of fatty liver diagnosed by ultrasound, of which 287 cases were male (51.9%), 129 cases were female (28.9%), the difference between them was statistically significant (蠂 ~ (2 +) 54.011) (P 0.05), fatty liver group was overweight, obesity, disorder of glucose metabolism, hypertension, abnormal blood lipid. The prevalence of hyperuricemia was higher than that of non-fatty liver (P 0.05). Univariate analysis showed that body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, total cholesterol, low density lipoprotein, fasting blood glucose and uric acid in fatty liver group were higher than those in non-fatty liver group. The difference was statistically significant (P 0.05), and high density lipoprotein cholesterol (HDL-C) was significantly lower than that in non fatty liver group (P 0.05). The results of multivariate logistic regression showed that age, sex (male, body mass index, triglyceride, low density lipoprotein, fasting blood glucose) entered the regression equation (P 0.05). Conclusion overweight, obesity, hypertension, disorder of glucose metabolism, dyslipidemia, and hyperlipidemia were found in the regression equation. Hyperuricemia increases the risk of fatty liver disease. Age, sex, body mass index, triglyceride, low density lipoprotein, fasting blood glucose are risk factors for fatty liver.
【學(xué)位授予單位】:福建醫(yī)科大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2014
【分類號】:R575.5
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