本文選題：克羅恩病 + 糞便鈣衛(wèi)蛋白��； 參考：《蘇州大學》2016年碩士論文

【摘要】：【目的】目前國內關于克羅恩病(Crohn’S disease,CD)患者的糞便鈣衛(wèi)蛋白(fecal calprotectin,FC)與簡化克羅恩病內鏡評分標準(SESCD)、血清學指標、CDAI之間的相關性研究以及其對克羅恩病病情評估能力等方面的研究較少。本研究的主要目的:一是評估糞便鈣衛(wèi)蛋白和SESCD、血清學指標和CDAI之間的相關性。二是研究糞便鈣衛(wèi)蛋白對克羅恩病病情評估的能力�！痉椒ā恳晕以合圃�2013年11月份至2016年1月份收治的資料完整的克羅恩病患者為研究對象。記錄每例研究對象的基本情況、病史、血清學檢查、糞便鈣衛(wèi)蛋白濃度、內鏡檢查、影像學檢查信息,共20例。將數據錄入SPSS17.0 for Windows軟件進行統(tǒng)計學處理�！窘Y果】1.FC、CDAI、CRP、WBC、ESR、PLT、HB、ALB區(qū)分克羅恩病緩解期與活動期的能力:根據SESCD評分將患者分為2組:疾病活動組(SESCD3),15例(75%),疾病非活動組(SESCD≤3)5例(25%)。疾病活動組FC、CDAI、CRP、WBC、ESR、PLT中位數(四分位間距)分別為1800(IQR1000-1800)ug/g、213(100-350)、25(11-73.4)mg/L、6.4(5.1-7.5)×109/L、25(12-41)mm/H、315(235-370)×109/L,明顯高于疾病非活動組的105(62-221)ug/g、71.1(60.5-104.1)、6.8(3.65-7.2)mg/L、4.6(3.3-6)×109/L、6(5-8.5)mm/H、273(167-312.5)×109/L,除PLT外差異均有統(tǒng)計學意義(P0.05)。疾病活動組HB、ALB水平低于疾病非活動組,但無統(tǒng)計意義上的差異(P0.05)。2.FC、CDAI、CRP、WBC、ESR、PLT、HB、ALB區(qū)分疾病非活動期、輕度活動期、中重度活動期的能力:將分組細化為疾病非活動組(SESCD≤3)5例(25%),輕度活動組(4-10分)4例(20%),中重度活動組(≥11分)11例(55%)。進行3組之間的兩兩比較發(fā)現,只有FC在非活動期與輕度活動期(P0.017)、輕度活動期與中重度活動期之間有差別(P0.017)。3.spearman’s等級相關分析:SESCD與FC、CDAI、CRP、WBC、ESR、ALB的spearman’s等級相關系數分別為0.934、0.42、0.49、0.529、0.725、-0.454,均有統(tǒng)計學意義上的相關性(P0.05)。與SESCD的相關強度依次是FC、ESR、WBC、CRP、ALB、CDAI。而SESCD和PLT、HB無統(tǒng)計學意義上的相關性(P0.05)。FC與CDAI、CRP、WBC、ESR、ALB的spearman’s等級相關系數分別為0.466、0.583、0.574、0.678、-0.394,均有統(tǒng)計學意義上的相關性(P0.05),相關強度依次是ESR、CRP、WBC、CDAI、ALB。而FC和PLT、HB無統(tǒng)計學意義上的相關性(P0.05)。4.FC、ESR、CRP、CDAI、WBC、ALB預測內鏡下疾病活動的準確性:ROC曲線分析顯示FC、ESR、CRP、CDAI、WBC、ALB曲線下面積依次是1、0.94、0.913、0.867、0.833、0.84,與0.5相比具有統(tǒng)計學差異(P0.05)。ROC曲線分析得出的FC、ESR、CRP、CDAI、WBC、ALB預測內鏡下疾病活動的最佳截點值依次是221ug/g、11mm/H、9.15mg/L、141、5.05×109/L、40.95g/L�！窘Y論】1.FC、CDAI、CRP、WBC、ESR均能預測內鏡下克羅恩病的活動性炎癥,預測內鏡下疾病活動性炎癥的準確性大小依次是FC、ESR、CRP、CDAI、WBC。FC、ESR、CRP、CDAI、WBC預測內鏡下疾病的活動性炎癥的最佳截點值依次是221ug/g、11mm/H、9.15mg/L、141、5.05×109/L。2.在FC、CDAI、CRP、WBC、ESR中,只有FC在疾病非活動期與輕度活動期、輕度活動期與中重度活動性期之間有差別。3.與SESCD評分相關性最強的是FC,然后依次是ESR、WBC、CRP、ALB、CDAI。
[Abstract]:[Objective] at present, there are few studies on the fecal caldin (fecal calprotectin, FC) in Crohn 'S disease (CD) patients with the simplified endoscopic score standard for Crohn's disease (SESCD), the correlation between the serological index, CDAI and the ability to assess the disease condition of Crohn's disease. The first is to assess the correlation between fecal caldin and SESCD, serological indicators and CDAI. Two is the ability to evaluate the assessment of Crohn's disease by faecal caldin. [Methods] a complete group of Crohn patients from November 2013 to January 2016 in our hospital were studied. Basic conditions, medical history, serological examination, fecal caldin concentration, endoscopy, and imaging information, 20 cases. The data were recorded in SPSS17.0 for Windows software for statistical processing. [results] 1.FC, CDAI, CRP, WBC, ESR, PLT, HB, ALB differentiated the ability of Crohn's remission and activity: the patients were divided into 2 groups according to the SESCD score: The disease active group (SESCD3), 15 (75%), and 5 cases (25%) of the disease non active group (SESCD < 3). The median of the disease active group FC, CDAI, CRP, WBC, ESR, and PLT (four) are 1800 (IQR1000-1800) ug/g, 213 (100-350), 25 (11-73.4) mg/L, 6.4 (12-41), 25 (12-41) * * *, obviously higher than those of the disease non activity group /g, 71.1 (60.5-104.1), 6.8 (3.65-7.2) mg/L, 4.6 (3.3-6) x 109/L, 6 (5-8.5) mm/H, 273 (167-312.5) x 109/L, except PLT heterodyne (P0.05). The ability of moderate and severe active period: 5 cases (SESCD < 3) was divided into 5 cases (25%), 4 cases (20%) of mild activity group (20%), and 11 cases (55%) in moderate and severe activity group (55%). The results of 3 groups were found, only FC was in the inactive and mild period (P0.017), and there was a difference between mild and moderate and severe active period (P (0.017).3.spearman 's level correlation analysis: SESCD and FC, CDAI, CRP, WBC, ESR, ALB Spearman' s rank correlation coefficient respectively. P0.05, CDAI, CRP, WBC, ESR, ALB Spearman 's grade correlation coefficients are 0.466,0.583,0.574,0.678, -0.394, and there are statistical correlations (P0.05). ROC curve analysis shows that FC, ESR, CRP, CDAI, WBC, the area under the ALB curve is 1,0.94,0.913,0.867,0.833,0.84, compared with 0.5, there is a statistical difference (P0.05).ROC curve analysis. /L. [Conclusion] 1.FC, CDAI, CRP, WBC, ESR can predict the active inflammation of the endoscopic Crohn's disease. The accuracy of predicting the accuracy of active inflammation in endoscopy is FC, ESR, CRP, CDAI, WBC.FC. In FC, CDAI, CRP, WBC, and ESR, only FC was in the period of disease inactivity and mild activity, and there was a difference between.3. and SESCD score between the mild and moderate and severe active stages, and FC was the strongest, followed by ESR, WBC, CRP, and SESCD.
【學位授予單位】：蘇州大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R574.62

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