本文選題：丙型肝炎病毒 + 冠狀動(dòng)脈疾病�。� 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:評(píng)價(jià)丙型肝炎肝病毒感染是否是粥樣硬化性疾病的危險(xiǎn)因素。方法:檢索了中文科技期刊全文數(shù)據(jù)庫(kù)、萬(wàn)方數(shù)據(jù)庫(kù)、pubmed、cochrance、scopus、Embase數(shù)據(jù)庫(kù)、中國(guó)生物醫(yī)學(xué)數(shù)據(jù)庫(kù)等數(shù)據(jù)庫(kù)。嚴(yán)格按下文所述納入排除標(biāo)準(zhǔn),收集丙型肝炎病毒感染與冠狀動(dòng)脈粥樣硬化性疾病發(fā)病風(fēng)險(xiǎn)的相關(guān)研究。采用Newcastle-Ottawa質(zhì)量評(píng)價(jià)量表進(jìn)行質(zhì)量評(píng)價(jià),利用Comprehensive Meta-Analysis version 2.0軟件進(jìn)行數(shù)據(jù)分析,繪制森林圖,并進(jìn)行亞組分析。結(jié)果:共納入13項(xiàng)關(guān)于丙型肝炎病毒感染與冠狀動(dòng)脈粥樣硬化性相關(guān)疾病發(fā)病風(fēng)險(xiǎn)的研究。meta分析發(fā)現(xiàn),丙型肝炎病毒患者發(fā)生冠狀動(dòng)脈粥樣硬化相關(guān)疾病風(fēng)險(xiǎn)是非丙肝患者的1.3倍,OR=1.32(CI95%,1.05-1.66,P0.05)。根據(jù)研究設(shè)計(jì)方式、年齡、糖尿病、高血壓等對(duì)其進(jìn)行分層分析,年齡按50歲為分組的臨界值,糖尿病按流行人數(shù)的20%為分組的臨界值,高血壓組按流行人數(shù)的20%為臨界值。結(jié)果發(fā)現(xiàn)年齡50歲,丙型肝炎病毒患者發(fā)生冠狀動(dòng)脈粥樣硬化性心臟病的發(fā)病風(fēng)險(xiǎn)為1.28(95CI,1.04-1.59,P0.05),年齡50歲者總發(fā)病風(fēng)險(xiǎn)OR值為1.31(95%CI,0.94-1.82,P0.05),兩組無(wú)顯著性差異。20%以下患有高血壓的慢性丙型肝炎患者發(fā)生冠狀動(dòng)脈粥樣硬化性疾病的風(fēng)險(xiǎn)OR值為1.10(95%CI,0.60-1.82,P0.05),P0.05,無(wú)統(tǒng)計(jì)學(xué)意義。而20%以上患有高血壓的丙型肝炎患者發(fā)生冠狀動(dòng)脈粥樣硬化的風(fēng)險(xiǎn)OR值為1.39(95%CI,1.15-1.66,P0.05)。20%以下的有糖尿病的丙型肝炎患者發(fā)生冠狀動(dòng)脈粥樣硬化性疾病的發(fā)病風(fēng)險(xiǎn)OR值為1.08(95%CI,0.60-1.96,P0.05),無(wú)統(tǒng)計(jì)學(xué)意義。20%以上有糖尿病的丙型肝炎患者發(fā)生冠狀動(dòng)脈粥樣硬化性疾病的風(fēng)險(xiǎn)OR值為1.35(95%CI,1.08-1.68,P0.05)。結(jié)論:丙型肝炎病毒感染可以顯著增加冠狀動(dòng)脈粥樣硬化性心臟病的發(fā)病風(fēng)險(xiǎn)。
[Abstract]:Objective: to evaluate whether hepatitis C virus infection is a risk factor for atherosclerosis. Methods: the full text database of Chinese scientific and technological journals, the database of pubmeda cochranceus Embase, the database of Chinese biomedicine and so on were searched. Research on the risk of hepatitis C virus infection and coronary atherosclerotic disease was collected strictly according to the exclusion criteria described below. The Newcastle-Ottawa quality evaluation scale was used to evaluate the quality, the data was analyzed by Comprehensive Meta-Analysis version 2.0 software, the forest map was drawn, and the subgroup analysis was carried out. Results: a total of 13 studies on the risk of hepatitis C virus infection and coronary atherosclerotic diseases were included. The risk of coronary atherosclerotic diseases in patients with hepatitis C virus was 1.3 times as high as that in non-hepatitis C patients. According to the method of design, age, diabetes, hypertension and so on, the critical value of age is 50 years old, the critical value of diabetes is 20% of epidemic population, and the critical value of hypertension is 20% of epidemic population. It turned out to be 50 years old, The risk of coronary atherosclerotic heart disease in patients with hepatitis C virus was 1.2895 CI 1.04-1.59V P0.05, and the total risk OR of 50 years old was 1.3195% CI 0.94-1.82% P0.050.There was no significant difference between the two groups in the incidence of chronic hepatitis C with hypertension below 20%. The risk OR value of coronary atherosclerotic disease was 1.10 ~ 95 CI 0.60-1.82% P0.05 and P0.05, there was no statistical significance. The OR value of coronary atherosclerosis in more than 20% of patients with hepatitis C with hypertension was 1.390.95. The OR value of coronary atherosclerotic disease in patients with hepatitis C with diabetes was 1.15-1.66P0.05.20%, the OR value was 1.08c95 CI 0.60-1.96P0.05. The OR value of coronary atherosclerotic disease in more than 20% of hepatitis C patients with diabetes mellitus was 1.3595% and 1.08-1.68% (P 0.05). Conclusion: hepatitis C virus infection can significantly increase the risk of coronary atherosclerotic heart disease.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R512.63;R543.3

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本文編號(hào)：1935230