本文選題：肝硬化 + 腹水��； 參考：《中華醫(yī)院感染學雜志》2016年06期

【摘要】：目的研究血清細胞因子與肝硬化腹水感染的關系,為感染的預防和治療提供參考依據。方法選取2013年6月-2014年12月于醫(yī)院進行治療的38例肝硬化腹水感染患者為感染組,同期的38例肝硬化腹水未發(fā)生感染患者為非感染組,38名健康人員為正常組,將3組受試人員的血清細胞因子水平進行比較,同時比較感染組和非感染組中輕度、中度和重度腹水患者的檢測結果,以logistic分析上述指標與肝硬化腹水感染的關系。結果感染組患者血清細胞因子包括白介素6(IL-6)、白介素8(IL-8)、γ-干擾素(IFN-γ)及腫瘤壞死因子α(TNF-α)水平分別為(14.52±1.89)pg/ml、(16.64±1.99)pg/ml、(23.84±2.46)ng/L及(3.89±0.37)ng/ml,其均高于非感染組及正常組,非感染組則高于正常組;感染組輕度、中度、重度腹水者的檢測水平均高于非感染組,經logistic分析顯示,上述血清指標均與肝硬化腹水感染有密切的關系,差異有統計學意義(P0.05)。結論肝硬化腹水感染患者的血清細胞因子呈現高表達狀態(tài),應加強對該類患者血清細胞因子的監(jiān)測及干預。
[Abstract]:Objective to study the relationship between serum cytokines and ascites infection in cirrhotic patients. Methods from June 2013 to December 2014, 38 patients with cirrhotic ascites infection were selected as infection group, 38 patients without ascites infection as non-infection group, 38 healthy people as normal group, who were treated in hospital from June 2013 to December 2014. The levels of serum cytokines in the three groups were compared, and the results of mild, moderate and severe ascites were compared between the infected group and the non-infected group. The relationship between the above indexes and ascites infection in cirrhosis was analyzed by logistic. Results the levels of serum cytokines, including IL-6, IL-8, IFN- 緯, IFN- 緯 and TNF- 偽 in infected patients were 14.52 鹵1.89pg / ml, 16.64 鹵1.99g / ml, 23.84 鹵2.46)ng/L and 3.89 鹵0.37ngr / ml, respectively, which were higher than those in the non-infected group and the normal group, and were higher in the non-infected group than in the normal group. The detection level of severe ascites was higher than that of non-infection group. Logistic analysis showed that the above serum indexes were closely related to ascites infection of liver cirrhosis, and the difference was statistically significant (P 0.05). Conclusion the serum cytokines in patients with ascites infection due to cirrhosis are highly expressed, so the monitoring and intervention of serum cytokines in patients with ascites infection should be strengthened.
【作者單位】： 鄭州大學附屬洛陽市中心醫(yī)院消化內科;
【基金】：河南省衛(wèi)生廳重點基金資助項目(20120890)
【分類號】：R575.2
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本文編號：1879964