本文選題：慢性乙型肝炎 + 肝纖維化��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討慢性乙型肝炎(CHB)不同程度肝纖維化血管內(nèi)皮功能差異。方法:收集2015年4月至2015年12月在新疆醫(yī)科大學(xué)第一附屬醫(yī)院住院明確診斷CHB患者,根據(jù)肝組織學(xué)活檢肝纖維化程度分為4組。使用Endo-PAT2000內(nèi)皮功能檢測(cè)儀測(cè)定外周動(dòng)脈張力(PAT),并計(jì)算反應(yīng)性充血指數(shù)(RHI)作為評(píng)價(jià)內(nèi)皮功能指標(biāo);檢測(cè)血生化指標(biāo),同時(shí)進(jìn)行肝臟瞬時(shí)彈性成像測(cè)定肝臟硬度值(LSM),采用Pearson相關(guān)分析RHI與LSM的相關(guān)性。結(jié)果:收集到CHB患者61例,其中S0組8例,S1組22例,S2組20例,S3組11例。S0組、S1組、S2組、S3組患者的RHI、LSM、總膽固醇、低密度脂蛋白、丙氨酸氨基轉(zhuǎn)移酶水平比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),S0組、S1組、S2組患者RHI為(1.93±0.30)、(1.78±0.38)和(1.63±0.16)高于S3組的(1.38±0.13)(P=0.00),S0組、S1組、S2組總膽固醇、低密度脂蛋白水平高于S3組差異有顯著性(P0.05)。S3組丙氨酸氨基轉(zhuǎn)移酶、LSM高于S0組、S1組、S2組差異有統(tǒng)計(jì)學(xué)意義(P0.01);患者RHI與LSM呈負(fù)相關(guān)(r=-0.323,P=0.011)。結(jié)論:在CHB患者隨著肝組織肝纖維化程度增加RHI降低,肝臟瞬時(shí)彈性硬度測(cè)定LSM與RHI負(fù)相關(guān),CHB患者隨著肝纖維化程度增加低密度脂蛋白、總膽固醇降低。
[Abstract]:Objective: to investigate the difference of vascular endothelial function in chronic hepatitis B (CHB) with different degrees of hepatic fibrosis. Methods: CHB patients were collected from April 2015 to December 2015 in the first affiliated Hospital of Xinjiang Medical University. The patients were divided into 4 groups according to the degree of liver fibrosis biopsy. The peripheral arterial tension was measured by Endo-PAT2000 endothelial function tester, and the reactive hyperemia index (RHI) was calculated as an index to evaluate endothelial function. At the same time, the liver hardness was measured by transient elastography, and the correlation between RHI and LSM was analyzed by Pearson correlation. Results: 61 cases of CHB were collected, including 8 cases of S0 group, 22 cases of S 1 group, 20 cases of S 2 group, 20 cases of S 3 group, 11 cases of S0 group S 1 group and S 2 group S 3 patients. The levels of RHI LSM, total cholesterol, low density lipoprotein (LDL) and alanine aminotransferase (alt) were compared. There was significant difference in RHI between S0 group and S0 group (1.93 鹵0.30, 1.78 鹵0.38) and 1.63 鹵0.16, respectively, which was higher than that in S3 group (1.38 鹵0.13), and the total cholesterol in S _ 1 group was higher than that in S _ 1 group. The level of low density lipoprotein was significantly higher than that of S3 group. There was a significant difference in the level of LSM between S0 group and S0 group. There was a significant difference between LSM and S0 group, and there was a negative correlation between RHI and LSM. Conclusion: in patients with CHB, RHI decreased with the increase of liver fibrosis degree, and the total cholesterol decreased with the increase of LDL-C in patients with CHB and negative correlation between LSM and RHI.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R512.62;R575.2

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