發(fā)布時間：2018-05-03 14:00

  本文選題：肝硬化 + 研究��； 參考：《中華疾病控制雜志》2015年04期

【摘要】：目的了解肝硬化患者腸道粘膜通透性的改變并探討其與Child-Pugh分級之間的相關性。方法納入66例肝硬化患者,并選擇40例健康體檢者作為對照,采用酶聯(lián)免疫吸附法(enzyme-linked immunosorbent assay,ELISA)檢測血二胺氧化酶(diamine oxidase,DAO)、D-乳酸水平,采用高效液相色譜法測定尿乳果糖/甘露醇(lactulose/mannitol,L/M)排泄率比來評價腸道粘膜通透性。結果肝硬化患者Child-Pugh分級各組的血DAO、D-乳酸水平及尿L/M排泄率比均明顯高于對照組,差異有統(tǒng)計學意義(均有P0.05)。血DAO水平與尿L/M排泄率比、血D-乳酸水平與尿L/M排泄率比均呈線性相關(r=0.518、r=0.527,均有P0.05)。血DAO水平、血D-乳酸水平及尿L/M排泄率比與Child-Pugh評分均呈正相關(rs=0.705、rs=0.791、rs=0.851,均有P0.05)。結論血DAO、D-乳酸水平及尿L/M排泄率比三種檢測指標能準確反映腸粘膜通透性的變化。肝硬化患者的腸粘膜通透性較對照組明顯增高,且與Child-Pugh評分呈正相關,腸粘膜通透性的檢測對肝硬化患者的治療有一定的臨床價值。
[Abstract]:Objective to understand the changes of intestinal mucosal permeability in patients with liver cirrhosis and to explore the correlation between Child-Pugh classification and methods. Methods the methods were included in 66 patients with liver cirrhosis, and 40 healthy subjects were selected as control, and the blood two amine oxidase (diamine oxidase, DAO) was detected by enzyme-linked immunosorbent assay (ELISA), D- The level of lactate (lactulose/mannitol, L/M) excretion rate was measured by high performance liquid chromatography (HPLC) to evaluate the permeability of intestinal mucosa. Results the blood DAO, D- lactate level and urine L/M excretion ratio of Child-Pugh groups in the patients with cirrhosis were significantly higher than those in the control group. The difference was statistically significant (P0.05). Blood DAO level. Compared with urine L/M excretion rate, the level of blood D- lactate and urine L/M excretion rate were linearly correlated (r=0.518, r=0.527, P0.05). Blood DAO level, serum D- lactate level and urinary L/M excretion rate were positively correlated with Child-Pugh score (rs=0.705, rs=0.791, all). The standard can accurately reflect the changes of intestinal permeability. The intestinal mucosal permeability of the patients with liver cirrhosis is significantly higher than that of the control group, and it has a positive correlation with the Child-Pugh score. The detection of intestinal mucosal permeability has certain clinical value for the treatment of patients with liver cirrhosis.

【作者單位】： 安徽醫(yī)科大學第一附屬醫(yī)院消化內(nèi)科;
【分類號】：R575.2

【參考文獻】

相關期刊論文 前2條

1 曾轉(zhuǎn)萍;廖日房;周衛(wèi)平;;影響肝硬化患者預后的多因素分析[J];中華疾病控制雜志;2009年01期

2 范才波;羅云;謝志翔;彭雷;陳海瓊;楊瓊英;黃光明;;肝硬化失代償期患者腸黏膜通透性的變化[J];檢驗醫(yī)學與臨床;2012年20期

【共引文獻】

相關期刊論文 前10條

1 鐘根明;;肝硬化患者口服四聯(lián)活菌片對腸道菌群和血漿細胞因子的影響[J];海峽藥學;2010年05期

2 賈百靈;杜蘭霞;褚燕君;;肝硬化患者血清二胺氧化酶和內(nèi)毒素檢測及臨床意義[J];中華實用診斷與治療雜志;2011年04期

3 徐義軍;王超;;乳果糖對門脈高壓大鼠腸粘膜屏障功能保護作用的研究[J];中外醫(yī)療;2010年12期

4 姜海彬;任旭;;潰瘍性結腸炎腸黏膜通透性的初步研究[J];黑龍江醫(yī)藥科學;2011年04期

5 徐瑞;李芳蘭;何振娟;施君;周一s，

本文編號：1838760