本文選題：冷沉淀 + 創(chuàng)面愈合　； 參考：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年28期

【摘要】：目的觀察血漿冷沉淀治療家兔感染性創(chuàng)面修復(fù)的效果,闡述血漿冷沉淀促進(jìn)家兔感染性創(chuàng)面修復(fù)的作用機(jī)制。方法將健康的新西蘭成年家兔12只,按照改良付小兵全層皮膚缺損法復(fù)制創(chuàng)傷感染性動(dòng)物體表潰瘍模型,分別予冷沉淀、康復(fù)新液、濕潤(rùn)燒傷膏和凡士林紗布換藥,測(cè)定治療后第3、7、12、17天創(chuàng)面微血管密度(MVD),創(chuàng)面愈合率和新生上皮覆蓋率,創(chuàng)面轉(zhuǎn)化生長(zhǎng)因子β_1(TGF-β_1)表達(dá)情況。結(jié)果各組治療第3天MVD均呈上升趨勢(shì),第3、7天冷沉淀組MVD與其他3組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),第12天后新生血管逐漸減少;冷沉淀組創(chuàng)面愈合率、新生上皮覆蓋率與康復(fù)新液組、凡士林組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),冷沉淀組創(chuàng)面完全愈合時(shí)間與其他3組比較,差異有統(tǒng)計(jì)學(xué)意義(H=11.169,P=0.011),冷沉淀組縮短;冷沉淀組治療早期TGF-β_1表達(dá)與其他3組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),并在整個(gè)修復(fù)過(guò)程中維持高表達(dá)。結(jié)論冷沉淀可能通過(guò)上調(diào)創(chuàng)面TGF-β_1表達(dá)、加速創(chuàng)面MVD,達(dá)到提高創(chuàng)面新生上皮覆蓋率,促進(jìn)創(chuàng)面快速愈合的目的。
[Abstract]:Objective to observe the effect of plasma cryoprecipitation on the repair of infectious wounds in rabbits, and to elucidate the mechanism of plasma cryoprecipitation in promoting the repair of infectious wounds in rabbits. Methods Twelve healthy New Zealand adult rabbits were used to establish the wound infected animal body surface ulcer model according to the modified Full-layer skin defect method. The models were treated with cold precipitation, Kangxin solution, MEBO and vaseline gauze respectively. The wound microvessel density (MVDX), wound healing rate and neonate epithelium coverage, and the expression of transforming growth factor 尾 1 (TGF- 尾 1) were measured on the 3rd day, 12th day, 17th day after treatment. Results on the 3rd day of treatment, MVD showed an increasing trend, the MVD of the cold precipitation group on the 3rd day was significantly higher than that of the other three groups, and the neovascularization gradually decreased on the 12th day, the wound healing rate of the cryoprecipitation group was higher than that of the other three groups. The rate of neonate epithelium coverage was significantly higher than that of the other three groups (P 0.05). The wound healing time of the cold precipitation group was significantly shorter than that of the other three groups, and the difference was statistically significant (P < 0.01). The cold precipitation group was shorter than that of the cold precipitation group (P < 0.05). The total wound healing time in the cold precipitation group was significantly higher than that in the other three groups. The expression of TGF- 尾 1 in the cryoprecipitation group was significantly higher than that in the other three groups, and the expression of TGF- 尾 1 remained high in the whole repair process. Conclusion Cold precipitation may accelerate wound MVD1 expression by up-regulating the expression of TGF- 尾 1, so as to increase the coverage of wound neonate epithelium and accelerate wound healing.
【作者單位】： 湖南師范大學(xué)第二附屬醫(yī)院(解放軍163醫(yī)院)肛腸外科;湖南師范大學(xué)第二附屬醫(yī)院(解放軍163醫(yī)院)病理科;湖南師范大學(xué)第二附屬醫(yī)院(解放軍163醫(yī)院)輸血科;
【基金】：湖南省教育廳項(xiàng)目(No:14C0711)
【分類號(hào)】：R-332;R574.8
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本文編號(hào)：1837387