本文選題：Barrett食管 + 射頻消融術(shù)　； 參考：《重慶醫(yī)科大學》2014年碩士論文

【摘要】：目的： 射頻消融術(shù)(RFA)是一種應用于治療Barrett食管（BE）的新興內(nèi)鏡技術(shù)本研究根據(jù)RFA術(shù)后患者的異型增生完全根除（CE-D）和腸上皮化生的完全根除（CE-IM）等指標，評價RFA治療BE患者的有效性和持久性 方法： 通過計算機檢索Pubmed Medline CNKI萬方等數(shù)據(jù)庫，經(jīng)過嚴格的納入排除標準搜集文獻，提取其中有效數(shù)據(jù)，計算出接受RFA的BE患者的CE-IM和CE-D率以及治療成功后腸上皮化生（IM）復發(fā)率，應用stata12.0軟件進行合并數(shù)據(jù)及進行統(tǒng)計學分析，計算不良事件發(fā)生率 結(jié)果： 納入研究共7篇（包括2477個樣本）評價治療效率，其中有4篇（171個樣本）評價了持久性患者達到CE-IM為84%（95%CI=0.74-0.94），，CE-D為85%（95%CI=0.78-0.93），治療患者病情進展為腺癌由其他級別的BE進展為HGD的比率為8%（95%CI=-0.03-0.2）,治療達到CE-IM的患者，腸上皮化生復發(fā)率為11%（95%CI=0.04-0.18）食管狹窄是最常見的不良事件，發(fā)生率為9%（95%CI=0.04-0.13） 結(jié)論： RFA治療Barrett食管患者所達到完全根除異型增生和腸化生的患者的比率較高，僅有少量的患者成功根除IM后出現(xiàn)腸上皮化生復發(fā)，治療中的不良事件發(fā)生率較低，所以RFA治療BE是安全有效并且持久的
[Abstract]:Objective: Radiofrequency ablation (RF) is a new endoscopic technique for the treatment of Barrett's esophagus. This study was designed to evaluate the efficacy and persistence of RFA in the treatment of patients with be according to the criteria of complete eradication of dysplasia (CE-D-) and complete eradication of intestinal metaplasia (CE-IMN) after RFA. Methods: The database of Pubmed Medline CNKI Wanfang and so on were searched by computer. The valid data were extracted through strict inclusion of exclusion criteria. The rates of CE-IM and CE-D in be patients receiving RFA and the recurrence rate of intestinal metaplasia after successful treatment were calculated. Combining data and statistical analysis with stata12.0 software to calculate the incidence of adverse events Results: A total of 7 articles (including 2, 477 samples) were included in the study to evaluate the efficacy of treatment. Of these, four (171 samples) evaluated the percentage of persistent patients who had reached CE-IM 84 / 95 and whose CE-D was 85 / 95CI0.78-0.93. The rate of progression from other levels of be to HGD was 8 / 95CI-0.03-0.2for patients who had been treated with CE-IM. The recurrence rate of intestinal metaplasia is 1195% CIQ 0.04-0.18) esophageal stenosis is the most common adverse event, and the incidence is 9% 95% CIQ 0.04-0.13) Conclusion: The rate of complete eradication of dysplasia and intestinal metaplasia was higher in patients with Barrett esophagus treated with RFA. Only a small number of patients had recurrence of intestinal metaplasia after successful eradication of IM, and the incidence of adverse events in treatment was lower. So RFA is safe, effective and persistent in treating be.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R571

【參考文獻】

相關(guān)期刊論文 前1條

1 廖專;李兆申;鄒多武;;Barrett食管診斷和內(nèi)鏡治療進展[J];世界華人消化雜志;2003年12期

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