本文選題：肝硬化 + 甲狀腺激素��； 參考：《浙江大學》2017年碩士論文

【摘要】：目的:研究肝硬化患者甲狀腺激素水平的變化,及與Child-Pugh分級、MELD評分之間的關(guān)系,評估肝硬化患者的肝功能與甲狀腺激素水平的關(guān)系,探討甲狀腺激素水平在肝硬化進展及診治中的臨床意義。方法:對2015年1月到2017年1月浙江大學附屬第一醫(yī)院住院的212例肝硬化患者進行統(tǒng)計分析,并選取40名同期健康體檢者作為對照組,比較兩組的血清甲狀腺激素水平。結(jié)果:不同病因的肝硬化患者的血清甲狀腺激素水平無統(tǒng)計學差異;代償期肝硬化與失代償期肝硬化僅在血清TT3、FT3水平上有顯著差異(P0.05);肝硬化患者Child-Pugh分級各組的血清TSH水平間無顯著性差異;在血清TT3水平上,對照組Child B 組Child C 組(P0.01),Child A 級Child B 組Child C 組(P0.05);在血清FT3、TT4水平上,對照組Child A組Child B組(P0.05),對照組Child A組Child C組(P0.05);對照組和Child C組的血清FT4水平均高于ChildA組、B組;血清TT3、FT3水平與Child-Pugh評分、MELD評分均呈顯著的強的負相關(guān)關(guān)系。結(jié)論:血清甲狀腺激素對肝硬化患者病情嚴重程度的判斷及預后的預測均有一定臨床價值,可以用于協(xié)助對肝硬化程度的判斷和預后的評估。
[Abstract]:Objective: to study the changes of thyroid hormone levels in patients with liver cirrhosis and the relationship between thyroid hormone levels and Child-Pugh grading and meld scores. To investigate the clinical significance of thyroid hormone level in the diagnosis and treatment of liver cirrhosis. Methods: 212 patients with liver cirrhosis hospitalized in the first affiliated Hospital of Zhejiang University from January 2015 to January 2017 were statistically analyzed and 40 healthy persons were selected as control group. The serum thyroid hormone levels were compared between the two groups. Results: there was no significant difference in serum thyroid hormone levels in patients with liver cirrhosis with different etiology. There was only a significant difference in serum TT3 FT 3 level between compensatory cirrhosis and decompensated cirrhosis (P 0.05). There was no significant difference in serum TSH level between Child-Pugh grading groups and serum TT3 level in patients with liver cirrhosis. In control group, Child B group, Child C group, control group Child A group Child B group, control group Child A group Child C group P 0.05, serum FT4 level in control group and Child C group were higher than that in ChildA group B group, and the levels of serum FT4 in control group Child A group were higher than those in ChildA group B group. There was a significant negative correlation between serum TT 3 FT 3 level and Child-Pugh score and meld score. Conclusion: serum thyroid hormone has certain clinical value in predicting the severity and prognosis of liver cirrhosis, and can be used to evaluate the severity and prognosis of cirrhosis.
【學位授予單位】：浙江大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R575.2

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本文編號：1828142