本文選題：幽門螺桿菌 + 潰瘍性結(jié)腸炎��； 參考：《新鄉(xiāng)醫(yī)學(xué)院》2017年碩士論文

【摘要】：背景幽門螺桿菌(Helicobacter pylori,HP)是慢性胃炎、消化性潰瘍、胃癌及胃粘膜相關(guān)性淋巴組織淋巴瘤的主要病因。近年來,有證據(jù)表明HP感染可通過免疫調(diào)節(jié)作用對(duì)某些免疫相關(guān)的疾病如過敏性哮喘、變應(yīng)性皮炎等發(fā)揮保護(hù)作用;IBD的病因和發(fā)病機(jī)制尚未完全明確,異常活躍的免疫反應(yīng)被認(rèn)為是IBD發(fā)病的主要因素,有研究表明HP感染對(duì)IBD的發(fā)生具有保護(hù)作用,目前二者之間的關(guān)系仍有爭(zhēng)議。本文通過研究初次診斷的IBD患者中HP感染情況,以期明確HP感染與IBD的關(guān)系。目的明確HP感染與IBD的關(guān)系。方法采用1:2配比病例對(duì)照研究,嚴(yán)格按照病例組和對(duì)照組的納入和排除標(biāo)準(zhǔn),選取100例初次診斷的IBD患者為病例組,選擇同時(shí)期就診的經(jīng)腸鏡檢查結(jié)果無器質(zhì)性病變或正常的200例健康體檢者為對(duì)照組,年齡、性別與病例組相匹配。采用酶聯(lián)免疫吸附法(ELISA)檢測(cè)血清Hp-IgG水平,Hp-IgG陽性者診斷為HP感染,比較病例組和對(duì)照組的HP感染情況,運(yùn)用Logistic回歸分析HP感染與IBD的相關(guān)性,并根據(jù)表型特征、病變程度的不同對(duì)IBD患者進(jìn)行分組,分別比較各亞組間的HP感染率有無差異。結(jié)果IBD組HP感染率為39.00%,低于對(duì)照組(59.00%),差異有統(tǒng)計(jì)學(xué)意義(P0.05),經(jīng)Logistic回歸分析,HP感染與IBD呈負(fù)相關(guān)(OR=0.450 95%CI=0.274-0.737P=0.002)。不同表型特征的IBD患者中的HP感染率差異無統(tǒng)計(jì)學(xué)意義(P0.05)。不同病變嚴(yán)重程度的IBD患者中的HP感染率差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論1.HP感染可能是IBD發(fā)病的保護(hù)性因素;2.HP感染與IBD的表型特征無相關(guān)性;3.HP感染與IBD的病變嚴(yán)重程度無明顯相關(guān)性。
[Abstract]:Background Helicobacter pylori (Helicobacter pylori) is the main cause of chronic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. In recent years, there has been evidence that HP infection can protect some immune-related diseases such as allergic asthma and allergic dermatitis through immunomodulation. The etiology and pathogenesis of IBD have not been completely clarified. Hyperactive immune response is considered to be the main factor in the pathogenesis of IBD. Some studies have shown that HP infection has protective effect on the occurrence of IBD, and the relationship between the two is still controversial. HP infection in patients with IBD was studied in order to determine the relationship between HP infection and IBD. Objective to investigate the relationship between HP infection and IBD. Methods A 1:2 matched case-control study was carried out. According to the inclusion and exclusion criteria of the case group and the control group, 100 patients with IBD were selected as the case group. In the same period, 200 patients who had no organic lesion or normal physical examination were selected as control group, age, sex and case group were matched. HP infection was detected by Elisa in patients with positive serum Hp-IgG level and Hp-IgG. HP infection was compared between case group and control group. Logistic regression analysis was used to analyze the correlation between HP infection and IBD, and according to phenotypic characteristics. Patients with IBD were divided into groups with different degree of lesion to compare the HP infection rate among subgroups. Results the HP infection rate in IBD group was 39.00, which was lower than that in control group (P 0.05). There was a negative correlation between HP infection and IBD by Logistic regression analysis. There was no significant difference in HP infection rate among IBD patients with different phenotypic characteristics (P 0.05). There was no significant difference in HP infection rate among IBD patients with different severity of disease (P 0.05). Conclusion 1.HP infection may be a protective factor in the pathogenesis of IBD. 2. There is no correlation between HP infection and phenotypic characteristics of IBD. 3. There is no significant correlation between HP infection and severity of IBD.
【學(xué)位授予單位】：新鄉(xiāng)醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R574

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