本文選題：肝炎 + 乙型��； 參考：《實用醫(yī)學(xué)雜志》2015年07期

【摘要】：目的:探討血清乙肝表面抗原(HBs Ag)定量檢測在預(yù)測干擾素治療HBe Ag陽性慢性乙型肝炎遠(yuǎn)期療效中的價值。方法:對75例HBe Ag陽性慢性乙型肝炎患者采用聚乙二醇干擾素α-2a,180μg,皮下注射,每周1次,連續(xù)48周后停用,完成治療后隨訪24周;治療及隨訪期間定期檢測血清HBs Ag及HBV DNA水平變化。結(jié)果:治療結(jié)束后隨訪24周,根據(jù)血清HBV DNA變化情況將患者分為病毒學(xué)持續(xù)應(yīng)答組、無應(yīng)答組及復(fù)發(fā)組。在治療第12、24及48周,持續(xù)應(yīng)答組與復(fù)發(fā)組相比,血清HBV DNA水平差異無顯著性,且均明顯低于無應(yīng)答組;而在治療第12、24及48周,持續(xù)應(yīng)答組血清HBs Ag定量檢測水平明顯低于復(fù)發(fā)組,復(fù)發(fā)組與無應(yīng)答組差異無顯著性。在治療第12周,血清HBs Ag水平下降幅度≥1 log10 IU/m L對預(yù)測持續(xù)病毒學(xué)應(yīng)答的敏感性、特異性、陽性預(yù)測值及陰性預(yù)測值分別為86%、94%、95%及94%;通過受試者工作特征曲線評估治療第12周血清HBs Ag水平下降幅度≥1 log10 IU/m L對預(yù)測患者病毒學(xué)持續(xù)應(yīng)答的價值,得出的曲線下面積為0.952。結(jié)論:血清HBV DNA水平的變化不能有效預(yù)測治療結(jié)束后患者能否達(dá)到持續(xù)病毒學(xué)應(yīng)答,但血清HBs Ag定量檢測可作為預(yù)測干擾素治療HBe Ag陽性慢性乙型病毒性肝炎患者療效的理想指標(biāo)。
[Abstract]:Objective: to evaluate the value of serum HBs Agb in predicting the long-term efficacy of interferon in the treatment of chronic hepatitis B (CHB) with HBe Ag positive.Methods: 75 patients with HBe Ag positive chronic hepatitis B were treated with polyethylene glycol interferon 偽 -2a1 180 渭 g, subcutaneously injected once a week, stopped for 48 weeks, followed up for 24 weeks.Serum HBs Ag and HBV DNA levels were measured regularly during treatment and follow-up.Results: the patients were followed up for 24 weeks after treatment. According to the changes of serum HBV DNA, the patients were divided into three groups: virological continuous response group, non-response group and recurrent group.At the 24th and 48th week of treatment, there was no significant difference in serum HBV DNA levels between the continuous response group and the recurrent group, and the level of serum HBV DNA was significantly lower than that in the non-response group, but at the 24th and 48th week after treatment, the serum HBV DNA level in the continuous response group was significantly lower than that in the recurrent group.The level of serum HBs Ag in the continuous response group was significantly lower than that in the recurrent group, but there was no significant difference between the recurrent group and the non-response group.At the 12th week of treatment, the sensitivity and specificity of serum HBs Ag decreased by 鈮，

本文編號：1759058