本文選題：超聲檢查 + 彈性成像技術(shù)�。� 參考：《中國醫(yī)學(xué)影像技術(shù)》2015年11期

【摘要】：目的探討肝纖維化指數(shù)(LF Index)與大鼠肝炎癥分級的相關(guān)性。方法對45只雄性SD大鼠尾靜脈注射豬血清誘導(dǎo)免疫性肝炎,7只雄性SD大鼠注射生理鹽水為正常對照組。于造模的第2、4、6、8、10、12和14周,從造模組與正常對照組分別隨機(jī)取6只和1只大鼠進(jìn)行實(shí)時(shí)組織彈性成像(RTE),得到LF Index。隨后處死大鼠,取肝組織進(jìn)行病理學(xué)檢查,并進(jìn)行肝炎癥分級。依照炎癥分級將大鼠分為正常對照組、G0亞組、G1亞組、G2亞組、G3亞組和G4亞組,比較各組的LF Index。結(jié)果 42只大鼠造模成功,其中炎癥分級為G0級、G1級、G2級、G3級和G4級的各有6、12、10、10和4只。LF Index與炎癥分級具有相關(guān)性(r=0.768,P0.05)。以LF Index繪制肝炎癥分級的ROC曲線,≥G1、≥G2、≥G3、G4的曲線下面積分別為0.851、0.911、0.928和0.853。結(jié)論炎癥分級與LF Index具有相關(guān)性,炎癥分級會影響LF Index評價(jià)肝纖維化程度的準(zhǔn)確性。
[Abstract]:Objective to investigate the correlation between liver fibrosis index (LF Index) and hepatic inflammation grade in rats.Methods 45 male SD rats were injected intravenously with porcine serum to induce immune hepatitis and 7 male SD rats were injected with normal saline as control group.At the 12th and 14th weeks, six rats and one rat were randomly selected from the model group and the normal control group for real-time tissue elastic imaging (RTET) to obtain LF Index.Then the rats were killed and the liver tissues were taken for pathological examination and liver inflammation grade.According to the grade of inflammation, the rats were divided into normal control group (G _ 0 subgroup), G _ 1 subgroup (G _ 2 subgroup) and G _ 3 subgroup and G _ 4 subgroup, and the LF Indexter of each group was compared.Results 42 rats were successfully established. Among them, there were 6 12 Index and 4% LF Index in G 0 grade, G 1 grade G 2 and G 2 group G 3 and G 4 grade, respectively. There was a correlation between the inflammation grade and the inflammation grade.The ROC curves of liver inflammation grade were plotted by LF Index. The areas under the curve of 鈮，

本文編號：1753561