本文選題：急性胰腺炎 + 血漿穿透素��； 參考：《中國老年學(xué)雜志》2017年05期

【摘要】：目的探討急性胰腺炎(AP)患者血漿穿透素(PTX)3水平的表達(dá)及臨床意義。方法 97例AP患者為研究組,按病情嚴(yán)重程度分為重度組(n=31)、中度組(n=32)和輕度組(n=34),另隨機(jī)選取80例健康體檢者作為對(duì)照組。采用酶聯(lián)免疫法(ELISA)分別檢測(cè)對(duì)照組入院第1天和AP患者入院第1、4、7天血清中PTX3水平。采用急性生理與慢性健康評(píng)分(APACHE)Ⅱ、嚴(yán)重程度床邊指數(shù)評(píng)分(BISAP)、Ranson評(píng)分評(píng)估病情嚴(yán)重程度,并分析血清中PTX3水平與以上評(píng)分的相關(guān)性。結(jié)果研究組入院第1天PTX3水平明顯高于對(duì)照組(P0.05);不同程度AP患者入院第1、4、7天組間PTX3水平比較均有統(tǒng)計(jì)學(xué)差異(均P0.05),以重度組為最高,中度組次之,輕度組最低(P0.05);隨著時(shí)間的推移,不同程度AP患者PTX3水平均呈下降趨勢(shì),入院第7天與第1天比較差異顯著(P0.05)。根據(jù)Pearson相關(guān)分析結(jié)果顯示,PTX3水平與APACHEⅡ評(píng)分、BISAP評(píng)分、Ranson評(píng)分均呈顯著正相關(guān)(r=0.883、0.832、0.749,均P0.05)。結(jié)論 PTX3水平可較好地反映AP患者病情進(jìn)展,可作為AP預(yù)后的預(yù)測(cè)指標(biāo)。
[Abstract]:Objective to investigate the expression and clinical significance of plasma penetin (PTX) 3 in patients with acute pancreatitis (AP).Methods 97 patients with AP were divided into two groups according to the severity of the disease. They were divided into severe group (31 cases) and mild group (32 cases) and mild group (n = 34). Another 80 healthy persons were randomly selected as control group.The serum PTX3 levels in the control group on the first day of admission and the AP patient on the 4th day of admission were detected by enzyme linked immunosorbent assay (Elisa).Acute physiological and chronic health scores were used to evaluate the severity of the disease. The severity index score (BISAP / Ranson score) was used to evaluate the severity of the disease, and the correlation between the serum PTX3 level and the above scores was analyzed.Results the level of PTX3 in the study group was significantly higher than that in the control group on the first day of admission, and the level of PTX3 in the patients with different degrees of AP was significantly higher than that in the control group on the 7th day after admission (P 0.05), the highest in the severe group and the second in the moderate group.With the passage of time, the PTX3 level of AP patients with different degrees showed a downward trend, and there was a significant difference between the 7th day of admission and the first day of admission.According to the results of Pearson correlation analysis, there was a significant positive correlation between the level of PTX3 and the APACHE 鈪，

本文編號(hào)：1752558