本文選題：苦參素 + 乙肝　； 參考：《中國(guó)老年學(xué)雜志》2017年13期

【摘要】：目的探討苦參素治療老年乙肝肝硬化的療效及對(duì)門脈血流動(dòng)力學(xué)的影響。方法 96例老年乙型肝硬化患者隨機(jī)分為對(duì)照組和觀察組各48例,對(duì)照組予常規(guī)治療,觀察組加用苦參素膠囊,24 w為1個(gè)療程。比較病毒活性、肝纖維化指標(biāo)和門脈血流動(dòng)力學(xué),記錄不良反應(yīng)。結(jié)果治療后觀察組乙型肝炎病毒(HBV)-DNA轉(zhuǎn)陰率高于對(duì)照組(P0.05)。觀察組肝纖維化指標(biāo)透明質(zhì)酸(HA)、Ⅳ型膠原(ⅣC)和層黏連蛋白(LN),門脈血流動(dòng)力學(xué)指標(biāo)門靜脈及脾靜脈的平均流速及脾靜脈血流量改善均較對(duì)照組明顯(P0.05)。其余指標(biāo)相近。兩組均未觀察到明顯不良反應(yīng)。結(jié)論苦參素治療老年慢性乙肝肝硬化安全且有效。
[Abstract]:Objective to investigate the effect of matrine on liver cirrhosis and portal hemodynamics in elderly patients.Methods 96 elderly patients with cirrhosis B were randomly divided into control group (n = 48) and observation group (n = 48). The control group was treated with routine therapy and the observation group was treated with matrine capsule for 24 weeks as a course of treatment.Virus activity, hepatic fibrosis index and portal hemodynamics were compared, and adverse reactions were recorded.Results the negative rate of HBV-DNA in the observation group was higher than that in the control group (P 0.05).Compared with the control group, the indexes of hepatic fibrosis, such as hyaluronate, collagen type 鈪，

本文編號(hào)：1748412