本文選題：消化系統(tǒng)損傷 + 抗凝或抗血小板藥物　； 參考：《中國老年學(xué)雜志》2015年15期

【摘要】：目的評估抗凝及抗血小板藥物造成消化系統(tǒng)損傷的臨床特點和相關(guān)因素。方法收集該院收治的接受抗凝和(或)抗血小板藥物(華法林、阿司匹林、氯吡格雷等)治療的老年住院患者200例,未接受治療老年患者100例,根據(jù)患者服用抗凝/抗血小板藥物狀況分為對照組和服藥組,對各組患者的一般人口資料、消化道出血程度、出血方式、內(nèi)鏡檢查特征等相關(guān)因素與患者服藥類型及(INR)值進(jìn)行統(tǒng)計學(xué)分析。結(jié)果服藥組患者出現(xiàn)消化道出血發(fā)生率較對照組高(P=0.003),且嘔血、便血及潛血陽性的發(fā)生率較對照組患者高(P=0.024,0.012,0.011),服藥組INR≥3患者的比例和出血風(fēng)險較對照組顯著增高(P=0.008),服藥組患者在胃竇、胃體及多發(fā)性潰瘍發(fā)生率較對照組高(P=0.035,0.013和0.013),且潰瘍面積(大潰瘍、小潰瘍)較對照組多(P=0.042,0.034),幽門螺桿菌感染率較對照組顯著增高(P=0.01)。結(jié)論老年患者服用抗凝和/或抗血小板藥物可能成為患者出現(xiàn)嚴(yán)重消化道出血、潰瘍及不同程度感染的危險因素。
[Abstract]:Objective to evaluate the clinical characteristics and related factors of digestive system injury caused by anticoagulant and antiplatelet drugs.Methods 200 elderly inpatients treated with warfarin, aspirin, clopidogrel, and 100 elderly patients who were not treated with anticoagulant and / or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.) were collected.According to the status of anticoagulant / antiplatelet drugs, the patients were divided into two groups: control group and medication group.The characteristics of endoscopic examination and other related factors were statistically analyzed with the type of medication and the value of INR.Results the incidence of gastrointestinal hemorrhage in the drug group was higher than that in the control group.The positive rate of stool blood and occult blood was higher than that of the control group. The proportion and bleeding risk of patients with INR 鈮，

本文編號：1732553