本文選題：結(jié)腸黑變病　切入點(diǎn)：性別　出處：《新疆醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的：探討新疆地區(qū)漢族和維吾爾族結(jié)腸黑變病(Melanosis Colon, MC)患者內(nèi)鏡下特征及其與性別、年齡、種族、結(jié)腸息肉、結(jié)腸惡性腫瘤之間的關(guān)系。方法：對(duì)2006年1月至2014年1月間行腸鏡檢出的851例漢族及維吾爾族MC患者的臨床資料(患者性別、年齡、民族、主訴)、鏡下表現(xiàn)、病理學(xué)檢查及合并癥等結(jié)果進(jìn)行回顧性分析。與同期行腸鏡檢查的漢族及維吾爾族非MC患者的相關(guān)資料進(jìn)行對(duì)比,比較兩組之間是否有異同。結(jié)果：在44568例行腸鏡檢查的漢族及維吾爾族患者中發(fā)現(xiàn)851例結(jié)腸黑變病患者(1.91%),其中漢族472例,維吾爾族379例,男性264例,女性587例,平均年齡55.02±14.14歲,與同期非MC患者相比,年齡大于65歲、女性、維吾爾族更易發(fā)生結(jié)腸黑變病(P值均0.001)。851例MC患者中有便秘史者593例,使用瀉劑者419例,其中315例使用過蒽醌類瀉藥。MC患者中最主要的臨床表現(xiàn)是便秘,其次是腹痛和無癥狀體檢。在黑變病的分布中,累及全結(jié)腸者663例(77.91%),其次為直腸乙狀結(jié)腸79例(9.28%)；從黑變病嚴(yán)重程度來看,重度黑變病主要發(fā)生在橫結(jié)腸(89例,10.45%),其次為降結(jié)腸和乙狀結(jié)腸的交界處(71例,8.34%),直腸黑變病程度一般較輕。851例MC患者中合并結(jié)腸息肉者179例,合并結(jié)腸惡性腫瘤24例,與同期非MC組相比無統(tǒng)計(jì)學(xué)差異(P值分別為0.057,0.755)。結(jié)論：老年人及女性易患本病,維吾爾族中MC檢出率高于漢族,提示遺傳、種族可能是MC的發(fā)病原因之一,或與各地區(qū)飲食生活習(xí)慣相關(guān)。
[Abstract]:Objective: to investigate the endoscopic features and their association with sex, age, race and colonic polyps in patients with Melanosis colonization (MCG) of Han and Uygur in Xinjiang. Methods: the clinical data of 851 patients with MC of Han nationality and Uygur nationality (gender, age, nationality, chief complaint, under microscope) from January 2006 to January 2014 were analyzed. The results of pathological examination and complications were analyzed retrospectively. The results were compared with those of non-MC patients of Han and Uygur nationality who underwent enteroscopy at the same time. Results: 851 cases of colonic melanosis were found in 44568 cases of Han and Uygur patients, including 472 cases of Han nationality, 379 cases of Uygur nationality, 264 cases of male and 587 cases of female, with an average age of 55.02 鹵14.14 years. Compared with the non-MC patients in the same period, 593 cases had constipation history and 419 cases were treated with cathartic agent, compared with non-MC patients in the same period, female and Uygur were more susceptible to colonic melanosis (P = 0.0010.851). Constipation was the main clinical manifestation of 315 patients who had used anthraquinone laxative .MC, followed by abdominal pain and asymptomatic physical examination. In 663 cases with total colon involvement, 77.91 cases were involved, followed by 79 cases of rectosigmoid colon and 9.28%. Judging from the severity of melanosis, Severe melanosis mainly occurred in 89 cases of transverse colonic carcinoma, followed by descending colon and sigmoid colon junction in 71 cases. The degree of rectal melanosis was generally mild .851 cases of MC patients had 179 cases of colonic polyps and 24 cases of malignant tumor of colon. There was no significant difference in P value between the non-MC group and the non-MC group in the same period. Conclusion: the prevalence rate of MC in the elderly and women is higher than that in the Han nationality, suggesting that heredity, race may be one of the causes of MC. Or related to eating and living habits in various regions.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R574.62
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本文編號(hào)：1681733