本文選題：伊托必利　切入點：多潘立酮　出處：《廣西醫(yī)科大學》2015年碩士論文

【摘要】：目的：采用Meta分析的方法,全面探討伊托必利(itopride)對比多潘立酮(domperidone)治療功能性消化不良(functional dyspepsia, FD)的療效及安全性。方法：使用計算機檢索PubMed、Cochrane Library、Embase、清華同方數(shù)據(jù)庫(CNKI)、中國生物醫(yī)學文獻數(shù)據(jù)庫(CBM)、維普數(shù)據(jù)庫(VIP)及萬方數(shù)據(jù)庫(WANGFANG)2015年2月以前公開發(fā)表的期刊文獻,選用“功能性消化不良”、“伊托必利”、“多潘立酮”等作為主題詞、自由詞,全面檢索有關(guān)伊托必利對比多潘立酮治療功能性消化不良的隨機對照實驗(RCT),對一切符合納入標準的臨床研究進行Meta分析。由兩個獨立的評價人按照Jadad改良法評分標準對所納入的研究進行方法學質(zhì)量評價,并對試驗組和對照組的各種臨床癥狀緩解情況、胃動力緩解情況、總體緩解率以及總不良反應(yīng)的發(fā)生率等指標進行相應(yīng)的數(shù)據(jù)提取,并選用Cochrane協(xié)作網(wǎng)提供的Revman 5.2軟件對所有提取的數(shù)據(jù)進行Meta分析。結(jié)果：依照制定的納入、排除標準,共納入Jadad改良法評分≥4分的13篇高質(zhì)量RCT,總計2002例FD患者,將患者隨機分為給予伊托必利治療的試驗組(1016例)以及給予多潘立酮治療的對照組(986例)。Meta分析結(jié)果顯示：伊托必利治療FD的總有效率[OR=3.26,95%CI(1.91,5.57),P0.0001]、早飽緩解率[OR=2.12,95%CI(1.14,3.95), P=0.02]、上腹飽脹緩解率[OR=1.51,95%CI(1.14,2.02), P=0.005]均高于多潘立酮,且兩組之間的差異具有統(tǒng)計學意義。伊托必利治療FD的惡心[OR=1.74,95%CI(0.71,4.28),P=0.22]、暖氣[OR=1.45,95%CI(0.45,2.46), P=0.17]、食欲不振[OR=1.33,95%CI(0.37,4.80), P=0.66]、反酸[OR=1.45,95%CI(0.60,3.46), P=0.41]及上腹疼痛[OR=1.34,95%CI(0.82,2.20), P=0.25]等癥狀的緩解率及胃腸動力學改善率[OR=1.30,95%CI(0.48,3.49), P=0.61]均高于多潘立酮,但兩組之間的差異并無統(tǒng)計學意義。多潘立酮治療FD的嘔吐[OR=0.81,95%CI(0.15,4.31),P=0.81]、上腹不適[OR=0.99,95%CI(0.65,1.52), P=0.98]及燒心[OR=0.91,95%CI(0.41,2.02), P=0.82]等癥狀的緩解率均高于伊托必利,但兩組之間的差異并無統(tǒng)計學意義。伊托必利治療FD的總不良反應(yīng)發(fā)生率低于多潘立酮,且兩組之間的差異具有統(tǒng)計學意義[OR=0.66,95%CI(0.46,0.93),P=0.02]。結(jié)論：總體而言,伊托必利治療功能性消化不良的總有效率優(yōu)于多潘立酮,且總不良反應(yīng)的發(fā)生率低。對各癥狀及胃腸動力學而言,伊托必利緩解早飽及上腹飽脹的療效優(yōu)于多潘立酮,其余諸如惡心、上腹疼痛、噯氣、嘔吐等癥狀的緩解及胃排空的改善,兩者無顯著性差異。
[Abstract]:Objective: to adopt the method of Meta analysis, To investigate the efficacy and safety of itopridea versus domperidoneon in the treatment of functional dyspepsia (FDD). Methods: computer search was used to search PubMedan Cochrane Library Embase, Tsinghua Tongfang database CNKIN, Chinese Biomedical Literature Database (CBMCBM), Wiper. Database VIPs and Wanfang Database Wangfag, published before February 2015, Choose "functional dyspepsia", "Itopiride", "domperidone" as the theme words, free words, A randomized controlled trial of itopride versus domperidone in the treatment of functional dyspepsia was searched for Meta analysis of all clinical studies that met the inclusion criteria. Two independent evaluators scored according to the improved Jadad method. Criteria for methodological quality evaluation of included research, The clinical symptoms, gastric motility, the overall remission rate and the incidence of total adverse reactions of the experimental group and the control group were extracted. All the extracted data were analyzed by Meta with Revman 5.2 software provided by Cochrane Cooperative Network. Results: according to the standard of inclusion and exclusion, 13 pieces of high quality Jadad with improved Jadad score 鈮，

本文編號：1681074