本文選題：腸脂肪酸結(jié)合蛋白　切入點(diǎn)：組氨酸脫羧酶　出處：《東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年06期

【摘要】：目的:探討腸脂肪酸結(jié)合蛋白(IFABP)、組氨酸脫羧酶(HDC)和二胺氧化酶(DAO)在絞窄性腸梗阻診斷中的意義。方法:選擇120例腸梗阻患者作為研究對(duì)象,其中絞窄性腸梗阻58例,單純性腸梗阻62例,并且選取同期健康對(duì)照者60例,檢測(cè)所有研究對(duì)象血清中IFABP、HDC和DAO的含量。結(jié)果:入院時(shí)血清IFABP、HDC和DAO含量絞窄性腸梗阻組均明顯高于單純性腸梗阻組;治療后同時(shí)間點(diǎn)血清IFABP、HDC和DAO含量絞窄性腸梗阻組均高于單純性腸梗阻組,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。絞窄性腸梗阻組血清IFABP、HDC和DAO含量隨著治療時(shí)間的延長(zhǎng)而呈增高趨勢(shì),并且各時(shí)間點(diǎn)之間差異有統(tǒng)計(jì)學(xué)意義(均P0.05);工作特征曲線下面積(AUC)值HDC高于FABP和DAO(分別為0.914、0.878、0.874),當(dāng)HDC的臨界值為30.00 ng·ml~(-1)時(shí),診斷絞窄性腸梗阻的靈敏度為74.03%,特異度為94.00%,假陰性率為25.12%,假陽(yáng)性率為5.00%,HDC對(duì)絞窄性腸梗阻的診斷價(jià)值明顯優(yōu)于IFABP和DAO。結(jié)論:IFABP、HDC和DAO可作為絞窄性腸梗阻的診斷指標(biāo),HDC的診斷價(jià)值優(yōu)于IFABP和DAO。
[Abstract]:Objective: to investigate the significance of intestinal fatty acid binding protein (IFABP), histidine decarboxylase (HDC) and diamine oxidase (diamine oxidase) in the diagnosis of strangulated intestinal obstruction. Methods: 120 patients with intestinal obstruction were selected as study subjects, including 58 patients with strangulated intestinal obstruction. 62 cases of simple intestinal obstruction and 60 cases of healthy control were selected to detect the contents of HDC and DAO in the serum of all the subjects. Results: the contents of HDC and DAO in serum of patients with simple intestinal obstruction were significantly higher than those of patients with simple intestinal obstruction at admission. At the same time after treatment, the levels of HDC and DAO in serum of strangulated intestinal obstruction group were higher than those in simple intestinal obstruction group, and the difference was statistically significant (P 0.05). The serum levels of IFABP HDC and DAO in strangulated intestinal obstruction group increased with the prolongation of treatment time. And there were significant differences among different time points (all P 0.05; area under working characteristic curve) HDC was higher than that of FABP and Dao (0.914 鹵0.878 鹵0.874g, respectively), and when the critical value of HDC was 30.00 ng / ml ~ (-1), The sensitivity, specificity, false negative rate, false positive rate and false positive rate in diagnosis of strangulated intestinal obstruction were 74.03 and 94.00, 25.12 and 5.00, respectively. Conclusion the diagnostic value of IFABP and DAO can be used as diagnostic index of strangulated intestinal obstruction. The diagnostic value of IFABP and Dao was superior to that of Dao.
【作者單位】： 鄂州職業(yè)大學(xué)醫(yī)學(xué)院普外科;
【分類號(hào)】：R574.2
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本文編號(hào)：1669726