本文選題：肥胖　切入點(diǎn)：Wnta　出處：《四川大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年01期 　論文類型：期刊論文

【摘要】：目的探討肥胖及超重人群中血清Wnt5a水平與肝臟脂肪變及纖維化程度的相關(guān)性。方法 134例在我院體檢中心參加體檢并在內(nèi)分泌代謝科就診,同時(shí)完成了瞬時(shí)彈性掃描儀(Fibroscan)檢查的肥胖或超重患者,根據(jù)Fibroscan檢測(cè)結(jié)果〔肝臟實(shí)時(shí)受控衰減參數(shù)(controlled attenuation parameter,CAP)評(píng)估肝臟脂肪變性程度,瞬時(shí)肝臟彈性測(cè)量值(elasticity,E)評(píng)估纖維化程度〕分為正常對(duì)照組(27例)、輕度非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)組(51例)和中重度NAFLD組(56例)。同時(shí)測(cè)量腰圍(waist circumstance,WC)、臀圍(hip circumstance,HC),進(jìn)行糖耐量試驗(yàn)和胰島功能試驗(yàn),檢測(cè)血清轉(zhuǎn)氨酶、血脂等,并采用酶聯(lián)免疫吸附法(ELISA)測(cè)定血清Wnt5a和β-連環(huán)蛋白(β-catenin)水平。結(jié)果對(duì)照組、輕度NAFLD組和中重度NAFLD組3組間年齡、性別、體質(zhì)量指數(shù)(BMI)、WC、HC差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。3組間空腹及餐后2h血糖、空腹胰島素水平和胰島素抵抗指數(shù)差異有統(tǒng)計(jì)學(xué)意義(P0.05),而餐后2h胰島素水平差異無統(tǒng)計(jì)學(xué)意義(P0.05)。輕度NAFLD組與對(duì)照組的CAP值、E值、血清Wnt5a和β-catenin水平相當(dāng),差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。中重度NAFLD組CAP值、E值和血清Wnt5a均高于對(duì)照組和輕度NAFLD組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。Spearman相關(guān)分析顯示,血清Wnt5a水平與CAP值呈負(fù)相關(guān)(相關(guān)系數(shù)r=-0.19,P0.000 1),與E值無顯著相關(guān)關(guān)系(r=0.02,P=0.241)。結(jié)論血清Wnt5a水平與NAFLD有關(guān),在肥胖或超重合并NAFLD的發(fā)病不同階段可能起著不同的病理生理作用。
[Abstract]:Objective to investigate the correlation between serum Wnt5a levels and hepatic steatosis and fibrosis in obese and overweight patients. At the same time, obese or overweight patients were examined by instantaneous elastic scanner. The degree of hepatic steatosis was evaluated according to the results of Fibroscan (controlled attenuation parameters CAPs). The instantaneous liver elasticity was assessed by ESR). The patients were divided into normal control group (n = 27), mild nonalcoholic fatty liver disease group (n = 51) and moderate and severe NAFLD group (n = 56). The waist circumference was measured at the same time. Volume test and islet function test, Serum levels of Wnt5a and 尾 -catenin were measured by Elisa. Results the age and sex of the control group, mild NAFLD group and moderate and severe NAFLD group were measured, and the serum levels of 尾 -catenin and 尾 -catenin in serum were measured by enzyme-linked immunosorbent assay (Elisa). There was no significant difference in body mass index (BMI) and WCU HC between the two groups (P 0. 05. 3) fasting and 2 h postprandial blood glucose. There were significant differences in fasting insulin level and insulin resistance index (P 0.05), but there was no significant difference in 2 h postprandial insulin level between mild NAFLD group and control group (P 0.05). The serum Wnt5a and 尾 -catenin levels in mild NAFLD group were similar to those in control group. There was no significant difference in CAP value and serum Wnt5a between moderate and severe NAFLD group, which was significantly higher than that in control group and mild NAFLD group. There was a negative correlation between serum Wnt5a level and CAP value (r = 0.19, P 0.000 1, P < 0.01), but no significant correlation between serum Wnt5a and E value. Conclusion Serum Wnt5a level is related to NAFLD, and may play different pathophysiological roles in different stages of obesity or overweight combined with NAFLD.
【作者單位】： 四川大學(xué)華西醫(yī)院全科醫(yī)學(xué)科;四川大學(xué)華西醫(yī)院實(shí)驗(yàn)醫(yī)學(xué)科;四川大學(xué)華西醫(yī)院內(nèi)分泌代謝科;
【基金】：四川省科技廳軟科學(xué)計(jì)劃項(xiàng)目(No.20152R0105和No.20142R0165)資助
【分類號(hào)】：R589.2;R575

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本文編號(hào)：1630813