本文選題：腹腔感染　切入點：營養(yǎng)管理　出處：《中華醫(yī)院感染學(xué)雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的探討營養(yǎng)支持管理方案在腹腔感染(IAI)患者中對腸道黏膜屏障及免疫功能的保護作用。方法前瞻性收集2015年2月-2016年10月醫(yī)院收治的IAI患者111例,分為研究組55例和對照組56例;研究組給予標(biāo)準(zhǔn)營養(yǎng)支持管理方案,對照組給予經(jīng)驗性營養(yǎng)支持,比較兩組患者一般臨床資料及營養(yǎng)指標(biāo)、腸道屏障指標(biāo)、炎癥指標(biāo)、免疫指標(biāo)和臨床預(yù)后的差異。結(jié)果兩組患者入院時一般臨床資料比較差異無統(tǒng)計學(xué)意義;研究組自第7天起血清白蛋白水平、血清前白蛋白水平、血清TNF-α水平、血清內(nèi)毒素水平、血清IgA及IgG水平與對照組相比,差異均有統(tǒng)計學(xué)意義(P0.05);第14天,研究組血清CRP水平顯著性低于對照組(t=4.147;P=0.000);第3天起研究組血清D-乳酸水平顯著性低于對照組(P0.05);研究組住院時間顯著低于對照組,差異有統(tǒng)計學(xué)意義(P0.05),但兩組病死率未見明顯統(tǒng)計學(xué)差異。結(jié)論營養(yǎng)管理可以有效地維持IAI患者營養(yǎng)狀態(tài),降低機體炎癥因子水平,保護腸道黏膜屏障功能,改善機體免疫功能,從而改善患者預(yù)后。
[Abstract]:Objective to investigate the protective effect of nutritional support management on intestinal mucosal barrier and immune function in patients with intraperitoneal infection. Methods 111 patients with IAI admitted in our hospital from February 2015 to October 2016 were collected prospectively. There were 55 cases in the study group and 56 cases in the control group, the study group was given the standard nutritional support management scheme, and the control group was given the experiential nutritional support. The general clinical data and nutritional index, intestinal barrier index, inflammatory index were compared between the two groups. Results there was no significant difference in the general clinical data between the two groups at admission, the serum albumin level, the serum prealbumin level, the serum TNF- 偽 level from the 7th day in the study group. The levels of serum endotoxin, serum IgA and IgG were significantly different from those of the control group (P 0.05). The serum CRP level in the study group was significantly lower than that in the control group (4.147), the serum D-lactic acid level in the study group was significantly lower than that in the control group (P 0.05) from the 3rd day, and the hospital stay in the study group was significantly lower than that in the control group. The difference was statistically significant (P 0.05), but there was no significant difference in mortality between the two groups. Conclusion Nutrition management can effectively maintain the nutritional status of IAI patients, reduce the level of inflammatory factors, protect the intestinal mucosal barrier function, and improve the immune function of the body. So as to improve the prognosis of patients.
【作者單位】： 嘉興市第三醫(yī)院消化內(nèi)科;嘉興市第三醫(yī)院ICU;嘉興市第三醫(yī)院急診科;
【基金】：浙江省醫(yī)藥衛(wèi)生一般研究計劃基金資助項目(2015KYB353)
【分類號】：R57

【相似文獻】

中國期刊全文數(shù)據(jù)庫 前10條

1 裘正軍;李寶華;;梗阻性黃疸對宿主細胞免疫功能的影響(文獻綜述)[J];國外醫(yī)學(xué).外科學(xué)分冊;1991年05期

2 王炳煌,王華;梗阻性黃疸對免疫功能的影響[J];醫(yī)師進修雜志;1997年09期

3 李祥金;楊晉輝;;原發(fā)性膽汁性肝硬化血清學(xué)免疫功能分析[J];云南醫(yī)藥;2006年05期

4 倪勇,方善德;阻塞性黃疸對免疫功能的影響[J];國外醫(yī)學(xué).外科學(xué)分冊;1990年02期

5 柳治國;;生長激素對急性出血壞死性胰腺炎大鼠免疫功能的影響[J];咸寧學(xué)院學(xué)報(醫(yī)學(xué)版);2007年06期

6 胡國潢,湯恢煥,呂新生;梗阻性黃疸時影響機體免疫功能的因素分析[J];中國現(xiàn)代醫(yī)學(xué)雜志;1999年09期

7 ;國外老年醫(yī)學(xué)集錦[J];實用老年醫(yī)學(xué);1991年03期

8 周玉;喻華;張春平;李焱鑫;黃文芳;朱世凱;;重癥急性胰腺炎患者早期免疫功能的變化及臨床意義[J];國際檢驗醫(yī)學(xué)雜志;2014年10期

9 蔡兵,嚴(yán)承銓,魯嚴(yán),唐建英,陶國清,張嵩海;圍手術(shù)期梗阻性黃疸免疫功能的變化[J];南通醫(yī)學(xué)院學(xué)報;1998年01期

10 ;[J];;年期

中國碩士學(xué)位論文全文數(shù)據(jù)庫 前2條

1 范衛(wèi)東;惡性重度梗阻性黃疸對機體免疫功能的影響及免疫增強劑的治療作用[D];大連醫(yī)科大學(xué);2013年

2 孫昭輝;超短波對腹瀉型腸易激綜合征患者免疫功能的影響[D];山東大學(xué);2009年

，

本文編號：1569020