發(fā)布時(shí)間：2018-03-04 05:35

  本文選題：脂肪肝　切入點(diǎn)：非酒精性　出處：《實(shí)用醫(yī)學(xué)雜志》2015年09期 　論文類型：期刊論文

【摘要】：目的:探討小細(xì)胞蛋白β基因(PARVB基因)rs5764455多態(tài)性與青島漢族人群非酒精性脂肪性肝病(NAFLD)遺傳易感性的相關(guān)性。方法:收集青島地區(qū)B型超聲診斷為NAFLD的患者(NAFLD組,n=230)及排除肝臟相關(guān)疾病的健康人群(對(duì)照組,n=330)。多聚酶鏈反應(yīng)及DNA測(cè)序法進(jìn)行PARVB基因型測(cè)定。檢測(cè)并比較各組人群臨床基本信息差異有無(wú)統(tǒng)計(jì)學(xué)意義。計(jì)算各組基因型頻率、等位基因頻率分布及發(fā)生NAFLD相對(duì)風(fēng)險(xiǎn)。結(jié)果:PARVB基因rs5764455位點(diǎn)基因型頻率及等位基因頻率在NAFLD組與對(duì)照組中的分布差異無(wú)統(tǒng)計(jì)學(xué)意義(基因型頻率χ2=0.182,P=0.913;等位基因頻率χ2=0.180,P=0.672)。校正體質(zhì)量、BMI等混雜因素前后,C/T+T/T基因型攜帶者與C/C基因型攜帶者相比,發(fā)生NAFLD的風(fēng)險(xiǎn)度無(wú)統(tǒng)計(jì)學(xué)差異(OR=1.266,P=0.178;校正OR=1.631,P=0.096)。與C/C基因型攜帶者相比,C/T+T/T基因型攜帶者體質(zhì)量、BMI、甘油三酯及ALT、AST升高且差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 :在青島漢族人群中,PARVB基因rs5764455多態(tài)性與NAFLD不相關(guān)。
[Abstract]:Objective: to investigate the association between the polymorphism of PARVB gene rs5764455 in small cell protein 尾 gene and the genetic susceptibility of non-alcoholic fatty liver disease (NAFLDD) in Qingdao Han population. Methods: the patients with NAFLD diagnosed by B-mode ultrasound in Qingdao were collected. PARVB genotypes were determined by polymerase chain reaction (PCR) and DNA sequencing. Results there was no significant difference in genotype frequency and allele frequency of rs5764455 locus between NAFLD group and control group (genotype frequency 蠂 2 / 0.182) and allele frequency (蠂 2 / 0.180) and allele frequency (蠂 ~ 2 / 0.180) were not significantly different between NAFLD group and control group (P < 0. 672). The carrier of C / T / T / T genotype was compared with the carrier of C / C genotype before and after adjusting body mass, BMI and other confounding factors. There was no statistical difference in the risk of occurrence of NAFLD. There was no statistical difference in the risk of occurrence of NAFLD. There was no statistical difference in the risk of occurrence of NAFLD. [WT5BZ] there was no statistical difference in the risk of occurrence of NAFLD. [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] there were significant differences in the body mass of C / T / T / T carriers compared with those of C / C carriers. Conclusion: there is a significant difference in P0.05in Qingdao Han population. Rs5764455 polymorphism was not associated with NAFLD.
【作者單位】： 青島大學(xué)醫(yī)學(xué)院附屬青島市市立醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(編號(hào):81170337/H0304) 青島市民生科技計(jì)劃項(xiàng)目(編號(hào):14-2-3-17-nsh)
【分類號(hào)】：R575

【共引文獻(xiàn)】

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