本文關(guān)鍵詞： 胰腺炎 急性壞死性 硫化氫 診斷 鑒別　出處：《重慶醫(yī)學(xué)》2017年04期 　論文類型：期刊論文

【摘要】：目的探討硫化氫(H2S)在急性胰腺炎(AP)嚴(yán)重性程度評價中的價值。方法選取2013年2月至2015年12月期間在該院住院的51例AP患者,其中21例為重癥AP(SAP)組,30例為輕性AP(MAP)組,同時抽取36例非胰腺炎腹痛患者(腹痛組),9例健康人作為對照組(NC組)。入院時抽取4組受試者外周靜脈血,并進(jìn)行Ranson評分。在12、24、48h后繼續(xù)抽取AP患者外周靜脈血,使用酶聯(lián)免疫吸附法(ELISA)監(jiān)測患者血清H2S水平。使用單因素方差分析和事后分析比較4組受試者入院時血清H2S水平,重復(fù)測量的方差分析比較AP患者入院時、12h、24h和48h時H2S水平,Spearman相關(guān)性分析AP患者血清H2S水平與Ranson評分的關(guān)系。結(jié)果入院時,SAP組的H2S水平顯著高于MAP組、腹痛組、NC組(P=0.000),MAP組的H2S水平也顯著高于腹痛組、NC組(P=0.000),而腹痛組和NC組差異無統(tǒng)計學(xué)意義(P=0.131);AP患者在入院時,12h,24h和48h時H2S水平差異均有統(tǒng)計學(xué)意義(P=0.000),呈逐漸下降的趨勢;AP組入院時的H2S水平與Ranson評分呈顯著正相關(guān)(r=0.578,P=0.000)。結(jié)論血清H2S對診斷患者是否存在AP發(fā)生的可能性上有明確意義,血清H2S水平越高,AP為SAP的風(fēng)險越大。
[Abstract]:Objective to evaluate the value of H2S in evaluating the severity of acute pancreatitis (AP). Methods 51 patients with AP were selected from February 2013 to December 2015, including 21 patients with severe APSAP (n = 30) and 30 patients with mild APAP MAPP (n = 30), who were hospitalized in the hospital from February 2013 to December 2015. At the same time, 36 patients with non-pancreatitis abdominal pain (9 healthy persons in the abdominal pain group) were selected as control group. Peripheral venous blood was taken from 4 groups of subjects on admission, and the Ranson score was evaluated. The peripheral venous blood of AP patients continued to be drawn after 1224 hours. The serum H2S levels were monitored by Elisa. The serum H2S levels were compared between the four groups at admission using one-way ANOVA and hindsight analysis. The relationship between serum H2S level and Ranson score in AP patients at 12h and 48h after admission. Results the H2S level in SAP group was significantly higher than that in MAP group at admission. The level of H2S in map group was significantly higher than that in NC group in abdominal pain group, but there was no significant difference between abdominalgia group and NC group. There were significant differences in H2S level in patients with AP at 12 hours after admission and 48 hours after admission, showing a decreasing trend of AP. There was a significant positive correlation between H2S level and Ranson score at admission. Conclusion Serum H2S has a definite significance in diagnosing the possibility of AP in patients. The higher the serum H 2S level, the greater the risk of AP being SAP.
【作者單位】： 重慶市第九人民醫(yī)院消化內(nèi)科;
【分類號】：R576

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