目的1.探討肝膽管結(jié)石相關(guān)肝內(nèi)膽管癌（HL-ICC）的危險(xiǎn)因素及臨床特征,提高診斷和治療水平。2.研究腫瘤標(biāo)志物CA199、癌胚抗原CEA對(duì)肝膽管結(jié)石相關(guān)肝內(nèi)膽管癌的診斷價(jià)值。3.比較增強(qiáng)CT、增強(qiáng)MRI、B超在肝膽管結(jié)石相關(guān)肝內(nèi)膽管癌中的診斷效果。方法:采用回顧性病例對(duì)照研究,收集湖南省人民醫(yī)院膽道外一科2010年1月—2012年12月間,其中肝膽管結(jié)石相關(guān)肝內(nèi)膽管癌患者有63例被納入為腫瘤組和同期單純肝膽管結(jié)石患者192例納入結(jié)石組,對(duì)相關(guān)因素采用單因素,并對(duì)單因素分析中存在統(tǒng)計(jì)學(xué)差異的因素采取logistic回歸模型多因素分析。收集上述病例一般資料、血清學(xué)指標(biāo)、影像學(xué)資料以及病理活檢結(jié)果,結(jié)合兩組病人收集的臨床數(shù)據(jù)分析影響診斷的因素。結(jié)果:1.單因素分析顯示,存在統(tǒng)計(jì)學(xué)差異的因素有:發(fā)病早期取石（P=0.002）、家族腫瘤史（P<0.001）、膽腸吻合手術(shù)史（P=0.022）、乙肝病史（P=0.023）。對(duì)單因素分析中存在統(tǒng)計(jì)學(xué)差異的因素采用Logistic回歸分析結(jié)果顯示:膽腸吻合手術(shù)史（OR=5.114,95%CI:1.734-15.097,P=0.004）,家族腫瘤史... 

【文章來(lái)源】：湖南師范大學(xué)湖南省 211工程院校

【文章頁(yè)數(shù)】：48 頁(yè)

【學(xué)位級(jí)別】：碩士

【文章目錄】：
摘要
Abstract
第一章 前言
第二章 方法與資料
第三章 結(jié)果與分析
第四章 討論
第五章 結(jié)論
參考文獻(xiàn)
綜述
    參考文獻(xiàn)
附錄
本人攻讀碩士期間發(fā)表論文情況
致謝


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