【摘要】：目的:研究分析骨氏葆方與膝關(guān)節(jié)內(nèi)粘療法聯(lián)合治療對腎虛血瘀型膝重度骨關(guān)節(jié)炎功能的治療效果與安全性。方法:腎虛血瘀型膝重度關(guān)節(jié)炎患者100例,按照隨機(jī)數(shù)字表法將其分為治療組和對照組各50例,兩組患者均給予膝關(guān)節(jié)內(nèi)粘療法和健康教育等基礎(chǔ)治療,在此基礎(chǔ)上給予對照組患者口服鹽酸氨基葡萄糖膠囊進(jìn)行治療,給予治療組患者骨氏葆方進(jìn)行治療,連續(xù)治療5周后觀察比較兩組患者的治療效果,并應(yīng)用中醫(yī)癥狀評分標(biāo)準(zhǔn)對兩組患者的臨床癥狀進(jìn)行評分,同時(shí)監(jiān)測兩組患者在治療前后的骨型堿性磷酸酶、降鈣素和血沉的變化狀況。結(jié)果:治療后兩組患者的血沉均顯著降低(P0.01),且治療組患者的降低程度顯著優(yōu)于對照組(P0.05),差異有統(tǒng)計(jì)學(xué)意義。但兩組患者的降鈣素和骨型堿性磷酸酶均無改善,其差異無統(tǒng)計(jì)學(xué)意義(P0.05)。治療后兩組患者的主要癥狀和體征積分均顯著降低(P0.05),且治療組患者的改善程度顯著優(yōu)于對照組(P0.01),其差異有統(tǒng)計(jì)學(xué)意義。治療后兩組患者的WOMAC評分、ISOA評分和疼痛評分均顯著降低(P0.01),但治療組患者的降低程度顯著優(yōu)于對照組(P0.01),其差異有統(tǒng)計(jì)學(xué)意義。治療組患者的總有效率(98.00%)顯著優(yōu)于對照組(82.00%),說明治療組患者的臨床療效顯著優(yōu)于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:骨氏葆方與膝關(guān)節(jié)內(nèi)粘療法聯(lián)合應(yīng)用能夠有效改善患者的臨床體征,降低患者血沉,是臨床上治療腎虛血瘀型膝重度關(guān)節(jié)炎的有效方案。
[Abstract]:Aim: to study the efficacy and safety of GuShi Bao recipe combined with intra-articular viscosity therapy in the treatment of severe osteoarthritis of the knee with kidney deficiency and blood stasis. Methods: 100 patients with severe arthritis of knee due to kidney deficiency and blood stasis were randomly divided into two groups: treatment group (n = 50) and control group (n = 50). On this basis, the patients in the control group were treated with oral glucosamine hydrochloride capsules, and the patients in the treatment group were treated with Gu Shi Bao Fang. After 5 weeks of continuous treatment, the therapeutic effects of the two groups were observed and compared. The clinical symptoms of the two groups were evaluated by TCM symptom scoring standard, and the changes of bone alkaline phosphatase, calcitonin and erythrocyte sedimentation rate (ESR) were monitored before and after treatment. Results: after treatment, the ESR of the two groups decreased significantly (P0.01), and the degree of decrease of the treatment group was significantly better than that of the control group (P0.05), the difference was statistically significant. There was no significant difference in calcitonin and bone alkaline phosphatase between the two groups (P0.05). After treatment, the scores of main symptoms and signs of the two groups were significantly decreased (P0.05), and the improvement of the treatment group was significantly better than that of the control group (P0.01), the difference was statistically significant. After treatment, the WOMAC score, ISOA score and pain score of the two groups were significantly decreased (P0.01), but the degree of decrease in the treatment group was significantly better than that in the control group (P0.01), and the difference was statistically significant. The total effective rate of the treatment group (98.00%) was significantly better than that of the control group (82.00%), indicating that the clinical efficacy of the treatment group was significantly better than that of the control group, the difference was statistically significant (P0.05). Conclusion: the combined application of Gu Shi Bao Fang and knee joint internal viscosity therapy can effectively improve the clinical signs of the patients and reduce the ESR of the patients. It is an effective scheme for the treatment of severe arthritis of the knee with kidney deficiency and blood stasis.
【作者單位】： 河北省中醫(yī)院骨傷二科;
【基金】：河北省中醫(yī)藥管理局項(xiàng)目(2016166)
【分類號】：R684.3
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本文編號：2460738