酪酸梭菌聯(lián)合抗菌藥物對急性闌尾炎患者腹腔鏡術(shù)后炎癥因子及胃腸功能的影響
發(fā)布時間：2019-02-25 19:55
【摘要】：目的:探討酪酸梭菌聯(lián)合抗菌藥物對急性闌尾炎患者腹腔鏡術(shù)后炎癥因子及胃腸功能的影響。方法:選擇2014年1月-2015年1月我院擬行腹腔鏡手術(shù)治療的急性闌尾炎患者102例,根據(jù)入院單雙號分為觀察組和對照組,各51例。對照組患者術(shù)后給予注射用頭孢呋辛鈉、甲硝唑葡萄糖注射液、頭孢克肟分散片抗感染治療;觀察組患者術(shù)后在對照組基礎(chǔ)上加用酪酸梭菌活菌膠囊1 260 mg,tid,連續(xù)服用3 d。比較兩組患者術(shù)前及術(shù)后3 d血清炎癥因子[腫瘤壞死因子α(TNF-α)、白細胞介素6(IL-6)、C反應(yīng)蛋白(CRP)]、胃動素(GAS)、胃泌素(MTL)水平,并記錄兩組患者胃腸功能恢復(fù)時間(腸鳴音出現(xiàn)時間、首次肛門排氣時間、術(shù)后首次排便時間)及并發(fā)癥發(fā)生情況。結(jié)果:術(shù)前,兩組患者血清炎癥因子、GAS、MTL水平比較,差異均無統(tǒng)計學意義(P0.05);術(shù)后3 d,兩組患者TNF-α、IL-6、CRP水平顯著降低,GAS、MTL水平顯著升高,且觀察組上述指標顯著優(yōu)于對照組,差異均有統(tǒng)計學意義(P0.05)。觀察組患者腸鳴音出現(xiàn)時間、首次肛門排氣時間、術(shù)后首次排便時間均明顯短于對照組,差異均有統(tǒng)計學意義(P0.05)。觀察組患者并發(fā)癥發(fā)生率為3.92%,顯著低于對照組的15.69%,差異有統(tǒng)計學意義(P0.05)。結(jié)論:酪酸梭菌聯(lián)合抗菌藥物能有效緩解急性闌尾炎腹腔鏡手術(shù)患者炎癥狀態(tài),促進胃腸功能恢復(fù),減少并發(fā)癥發(fā)生。
[Abstract]:Aim: to investigate the effects of Clostridium butyrate combined with antibiotics on inflammatory factors and gastrointestinal function after laparoscopic surgery in patients with acute appendicitis. Methods: 102 patients with acute appendicitis scheduled for laparoscopic surgery from January 2014 to January 2015 were divided into observation group (n = 51) and control group (n = 51). The patients in the control group were treated with cefuroxime sodium, metronidazole glucose injection and cefixime dispersible tablets. The patients in the observation group were treated with Clostridium butyricum capsule 1 260 mg,tid, on the basis of the control group for 3 d. The levels of serum inflammatory factors [tumor necrosis factor 偽 (TNF- 偽), interleukin 6 (IL-6), C reactive protein (CRP), motilin (GAS), gastrin (MTL)] were compared between the two groups before and 3 days after operation. The recovery time of gastrointestinal function (the appearance time of intestinal sound, the first time of anal exhaust, the time of first defecation after operation) and the occurrence of complications were recorded in the two groups. Results: before operation, there was no significant difference in the levels of serum inflammatory factors and GAS,MTL between the two groups (P0.05). On the 3rd day after operation, the levels of TNF- 偽 and IL-6,CRP in the two groups decreased significantly, while the level of GAS,MTL increased significantly, and the above indexes in the observation group were significantly better than those in the control group, the difference was statistically significant (P0.05). The time of bowel sounds, the first anal exhaust time and the first defecation time after operation in the observation group were significantly shorter than those in the control group (P0.05). The incidence of complications in the observation group was 3.92%, which was significantly lower than that in the control group (15.69%) (P0.05). Conclusion: Clostridium butyricum combined with antibiotics can effectively relieve the inflammatory state of patients undergoing laparoscopic appendicitis, promote the recovery of gastrointestinal function, and reduce the incidence of complications.
【作者單位】： 石河子大學醫(yī)學院第一附屬醫(yī)院胃腸乳腺外科;
【分類號】：R656.8
[Abstract]:Aim: to investigate the effects of Clostridium butyrate combined with antibiotics on inflammatory factors and gastrointestinal function after laparoscopic surgery in patients with acute appendicitis. Methods: 102 patients with acute appendicitis scheduled for laparoscopic surgery from January 2014 to January 2015 were divided into observation group (n = 51) and control group (n = 51). The patients in the control group were treated with cefuroxime sodium, metronidazole glucose injection and cefixime dispersible tablets. The patients in the observation group were treated with Clostridium butyricum capsule 1 260 mg,tid, on the basis of the control group for 3 d. The levels of serum inflammatory factors [tumor necrosis factor 偽 (TNF- 偽), interleukin 6 (IL-6), C reactive protein (CRP), motilin (GAS), gastrin (MTL)] were compared between the two groups before and 3 days after operation. The recovery time of gastrointestinal function (the appearance time of intestinal sound, the first time of anal exhaust, the time of first defecation after operation) and the occurrence of complications were recorded in the two groups. Results: before operation, there was no significant difference in the levels of serum inflammatory factors and GAS,MTL between the two groups (P0.05). On the 3rd day after operation, the levels of TNF- 偽 and IL-6,CRP in the two groups decreased significantly, while the level of GAS,MTL increased significantly, and the above indexes in the observation group were significantly better than those in the control group, the difference was statistically significant (P0.05). The time of bowel sounds, the first anal exhaust time and the first defecation time after operation in the observation group were significantly shorter than those in the control group (P0.05). The incidence of complications in the observation group was 3.92%, which was significantly lower than that in the control group (15.69%) (P0.05). Conclusion: Clostridium butyricum combined with antibiotics can effectively relieve the inflammatory state of patients undergoing laparoscopic appendicitis, promote the recovery of gastrointestinal function, and reduce the incidence of complications.
【作者單位】： 石河子大學醫(yī)學院第一附屬醫(yī)院胃腸乳腺外科;
【分類號】：R656.8
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