【摘要】：目的：對比注射透明質(zhì)酸與自體脂肪顆粒移植治療鼻唇溝皺褶的有效性和安全性。方法：60例鼻唇溝部皺紋嚴重程度分級在中度以上的患者隨機分為A、B兩組,每組各30人,A組接受透明質(zhì)酸注射治療,B組接受自體脂肪顆粒移植治療,隨訪12個月,分別由研究者和受試者根據(jù)皺紋嚴重程度評分表和面部整體美容效果改善分級進行評分,研究者記錄不良事件的發(fā)生情況。結(jié)果：兩組受試者使用填充物注射總劑量(注射劑量+補充劑量)B組大于A組(P0.05)；研究者和受試者分別在治療前后各個時間點評價鼻唇溝皺紋嚴重程度,治療后3個月,鼻唇溝皺紋嚴重程度的評分先是明顯下降,隨后治療后6、12個月的隨訪中評分略增高,但均未超過治療前評分；治療后12個月,研究者與受試者分別評價鼻唇溝皺紋嚴重程度(WSRS),B組評分低于A組(P0.05),即B組治療效果優(yōu)于A組；治療后12個月,研究者與受試者分別評價面部整體美容效果改善分級(GAIS),B組滿意率高于A組(P0.05)；治療后12個月內(nèi)發(fā)紅、瘙癢的發(fā)生率A組高于B組(P0.05),腫脹、疼痛和硬結(jié)的發(fā)生率兩組之間無差別(P0.05)。結(jié)論：在治療鼻唇溝皺褶方面,自體脂肪顆粒移植比注射透明質(zhì)酸的維持時間長、外形自然、并發(fā)癥少,值得推廣應用。
[Abstract]:Objective: to compare the efficacy and safety of injecting hyaluronic acid and autologous fat granules in the treatment of nasolabial crease. Methods: sixty patients with severe degree of wrinkle in nasolabial sulcus were randomly divided into two groups: group A received hyaluronic acid injection, group B received autogenous fat granule transplantation, and the patients were followed up for 12 months. According to the score of wrinkle severity scale and the overall facial beauty improvement grade, the researchers recorded the occurrence of adverse events. Results: the total dose of filling was higher in group B than in group A (P0.05). The researchers and subjects evaluated the severity of nasolabial furrow at different time points before and after treatment. After 3 months of treatment, the score of the severity of nasolabial furrow decreased significantly, then increased slightly during the follow-up of 6 months and 12 months after treatment. But none of them exceeded the score before treatment. At 12 months after treatment, the score of nasolabial furrow severity in (WSRS), B group was lower than that in A group (P0.05), that is, the therapeutic effect of group B was better than that of group A; 12 months after treatment, the satisfaction rate of (GAIS), B group was higher than that of A group (P0.05). Within 12 months after treatment, the incidence of pruritus in group A was higher than that in group B (P0.05). There was no difference in the incidence of swelling, pain and induration between the two groups (P0.05). Conclusion: in the treatment of nasolabial crease, autologous fat granule transplantation is worth popularizing because of its long maintenance time, natural appearance and less complications.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R622.9

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