發(fā)布時(shí)間：2018-12-12 07:42

【摘要】：現(xiàn)階段骨性關(guān)節(jié)炎(Osteoarthritis,OA)在人類中老年階段發(fā)病率較高,現(xiàn)代醫(yī)學(xué)實(shí)驗(yàn)已經(jīng)證明,患有前中期的骨性關(guān)節(jié)炎患者,用物理學(xué)的方法進(jìn)行干預(yù)是一種可行性方法。其中,用電磁場(chǎng)對(duì)骨性關(guān)節(jié)炎進(jìn)行干預(yù)就是眾多物理學(xué)方法的一種。隨著當(dāng)代磁場(chǎng)生物學(xué)研究的理論基礎(chǔ)不斷深入,其研究成果將不斷的應(yīng)用到實(shí)踐當(dāng)中。在生物力學(xué)中的一個(gè)重要分支就是骨生物力學(xué),它是研究骨骼遭受外力后的生物效應(yīng)和骨組織在外力作用下的力學(xué)特性,是判斷一個(gè)骨骼優(yōu)劣的基礎(chǔ)參考依據(jù)。所以本文通過研究兔子股骨各骨質(zhì)層體積的變化以及對(duì)股骨力學(xué)性能的評(píng)估,并運(yùn)用COMSOL軟件進(jìn)行仿真模擬兔子股骨周圍磁場(chǎng)分布。結(jié)合實(shí)驗(yàn)數(shù)據(jù)與仿真結(jié)果分析磁場(chǎng)的作用對(duì)患骨性關(guān)節(jié)炎兔子股骨的影響。本次實(shí)驗(yàn)將3只新西蘭大白兔隨機(jī)的分為兩組:實(shí)驗(yàn)組(2只)與對(duì)照組(1只)。實(shí)驗(yàn)組對(duì)成年新西蘭大白兔的右后腿股骨關(guān)節(jié)腔注射濃度為3%的木瓜蛋白酶使其破壞關(guān)節(jié)軟骨,建立典型的OA模型,然后將實(shí)驗(yàn)組的兔子放入磁療箱進(jìn)行物理干預(yù),對(duì)照組正常飼養(yǎng)不參與實(shí)驗(yàn)。接著通過醫(yī)學(xué)影像CT掃描獲取兔子股骨各骨質(zhì)層的體積,常規(guī)股骨生物力學(xué)實(shí)驗(yàn)獲取有相關(guān)力學(xué)性能參數(shù),之后對(duì)股骨骨質(zhì)層體積與力學(xué)實(shí)驗(yàn)數(shù)據(jù)進(jìn)行整合與分析。最后利用有限元的方法對(duì)實(shí)驗(yàn)結(jié)果進(jìn)行仿真,得出兔子股骨處磁感應(yīng)強(qiáng)度大小與磁場(chǎng)分布。與實(shí)驗(yàn)測(cè)的數(shù)據(jù)進(jìn)行比較,仿真結(jié)果與實(shí)驗(yàn)數(shù)據(jù)基本吻合。通過CT掃描結(jié)果可以看出在打藥后用75Hz磁場(chǎng)物理干預(yù)的兔子的右后腿股骨的各骨質(zhì)層的變化趨勢(shì)曲線相比用25Hz的曲線趨勢(shì)更趨于對(duì)照組;通過三點(diǎn)彎曲實(shí)驗(yàn)的結(jié)果可以看出用75Hz磁場(chǎng)物理干預(yù)的兔子右后腿股骨的最大承載載荷、斷裂強(qiáng)度以及最大彎曲正應(yīng)力均高于25Hz磁場(chǎng)干預(yù)的兔子。結(jié)論:75Hz的磁場(chǎng)在修復(fù)OA兔子的效果上更優(yōu)于25Hz的磁場(chǎng)。
[Abstract]:At present, the incidence of osteoarthritis (Osteoarthritis,OA) is relatively high in the middle and old age. Modern medical experiments have proved that physical intervention is a feasible method for patients with osteoarthritis. Intervention in osteoarthritis with electromagnetic fields is one of many physical methods. With the deepening of the theoretical foundation of contemporary magnetic field biology, its research results will be applied to practice. Bone biomechanics is an important branch of biomechanics. It is a basic reference for studying the biomechanical effect of bone under external force and the mechanical properties of bone tissue under external force. Therefore, this paper studies the changes of femoral bone layer volume and the evaluation of femoral mechanical properties, and simulates the distribution of magnetic field around the femur by using COMSOL software. The effect of magnetic field on femur of rabbits with osteoarthritis was analyzed with experimental data and simulation results. Three New Zealand rabbits were randomly divided into two groups: experimental group (n = 2) and control group (n = 1). The experimental group injected 3% papain into the femur of the right hind leg of adult New Zealand white rabbits to destroy the articular cartilage and set up a typical OA model. Then the rabbits of the experimental group were put into the magnetic therapy box for physical intervention. The control group did not participate in the experiment. Then the volume of bone layers of femur was obtained by CT scanning of medical image, and the parameters of mechanical properties were obtained by routine femoral biomechanical experiment, and then the volume of femoral bone layer and the data of mechanical experiment were integrated and analyzed. Finally, the finite element method is used to simulate the experimental results, and the magnitude of magnetic induction and magnetic field distribution in rabbit femur are obtained. Compared with the experimental data, the simulation results are in good agreement with the experimental data. The results of CT scan showed that the trend curve of femur of right hind leg of rabbits treated with 75Hz magnetic field physical intervention was more similar to that of control group compared with that of 25Hz. The results of three-point bending experiment show that the maximum load, fracture strength and maximum bending normal stress of femur of right hind leg of rabbits treated with 75Hz magnetic field are higher than those of rabbits treated with 25Hz magnetic field. Conclusion: the magnetic field of 75Hz is better than that of 25Hz in repairing OA rabbits.
【學(xué)位授予單位】：新疆大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R684.3

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本文編號(hào)：2374203