【摘要】：目的:探討神經(jīng)妥樂平對(duì)于脊髓損傷后神經(jīng)病理性疼痛的臨床療效,同時(shí)比較單獨(dú)使用神經(jīng)妥樂平與聯(lián)合使用普瑞巴林和神經(jīng)妥樂平對(duì)神經(jīng)病理性疼痛的緩解程度、對(duì)患者情緒以及睡眠狀況的改善情況。方法:選取符合入組標(biāo)準(zhǔn)的脊髓損傷伴神經(jīng)病理性疼痛患者62例,電腦隨機(jī)分2組,分別為神經(jīng)妥樂平組、普瑞巴林聯(lián)合神經(jīng)妥樂平組,神經(jīng)妥樂平組起始劑量為4U bid,普瑞巴林聯(lián)合神經(jīng)妥樂平組起始劑量為普瑞巴林75mg bid+神經(jīng)妥樂平4U bid,間隔3d調(diào)整藥物劑量,療程為4周。采用視覺模擬評(píng)分量表(visual analogue scale,VAS)、醫(yī)院焦慮抑郁量表(hospital anxiety and depression scale,HAD)、匹茨堡睡眠質(zhì)量指數(shù)量表(Pittsburgh sleep quality index,PSQI)對(duì)患者進(jìn)行疼痛、情緒和睡眠質(zhì)量的評(píng)估。由專業(yè)的康復(fù)治療師對(duì)患者服藥前和療程結(jié)束后的療效分別進(jìn)行評(píng)估。結(jié)果:單獨(dú)使用神經(jīng)妥樂平可以緩解脊髓損傷患者神經(jīng)病理性疼痛,同時(shí)改善患者睡眠質(zhì)量,治療前后比較差異有顯著性意義(P0.05);而聯(lián)合使用普瑞巴林和神經(jīng)妥樂平治療后,患者的VAS和HAD評(píng)分均較神經(jīng)妥樂平組明顯降低,差異有顯著性意義(P0.05)。結(jié)論:神經(jīng)妥樂平可以緩解脊髓損傷患者的疼痛癥狀,聯(lián)合使用普瑞巴林和神經(jīng)妥樂平不僅明顯緩解脊髓損傷神經(jīng)病理性疼痛患者的疼痛癥狀,同時(shí)顯著改善了患者的焦慮抑郁情緒,提高患者睡眠質(zhì)量,進(jìn)而提升患者生存質(zhì)量,是一種有效的臨床治療方法。
[Abstract]:Objective: to investigate the clinical effect of neuropathic pain after spinal cord injury (sci), and to compare the effect of neuropathic pain treated with neuropathic pain treated by neurotropin alone and combined with prazin and neurotropin. Improved mood and sleep status of patients. Methods: Sixty-two patients with spinal cord injury and neuropathic pain were randomly divided into two groups: neurotropin group, pragabine combined with neurotropin group, and neurotropin group with initial dose of 4 U bid,. The initial dose of preabine combined with neurotropin was adjusted 3 days after injection of 75mg bid neurotropin 4U bid,. The course of treatment was 4 weeks. Visual analogue scale (visual analogue scale,VAS), Hospital anxiety and Depression scale (hospital anxiety and depression scale,HAD) and Pittsburgh Sleep quality Index (Pittsburgh sleep quality index,PSQI) were used to evaluate pain, mood and sleep quality. Patients were evaluated before and after treatment by a professional rehabilitation therapist. Results: neuropathic pain was alleviated in patients with spinal cord injury and sleep quality was improved. There was significant difference before and after treatment (P0.05). However, the VAS and HAD scores of patients treated with prednisoline and neurotropin were significantly lower than those of neurotropin group (P0.05). Conclusion: neurotropin can relieve the pain symptoms of patients with spinal cord injury, and the combination of prazin and neurotropin can not only relieve the pain symptoms of patients with spinal cord injury neuropathic pain, but also can relieve the pain symptoms of patients with spinal cord injury neuropathic pain. At the same time, it can significantly improve the anxiety and depression of the patients, improve the sleep quality of the patients, and then improve the quality of life of the patients. It is an effective clinical treatment.
【作者單位】： 中山大學(xué)孫逸仙紀(jì)念醫(yī)院康復(fù)科;
【基金】：廣東省醫(yī)學(xué)科研基金項(xiàng)目(A2015308) 廣東省自然科學(xué)基金-重點(diǎn)項(xiàng)目(2016A030311045) 廣州市科學(xué)技術(shù)研究專項(xiàng)基金項(xiàng)目(201607010254)
【分類號(hào)】：R651.2

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