【摘要】：目的:檢測原發(fā)性雙側乳腺癌左右兩側病理石蠟切片中CEA和PTEN表達和表達強度差異,揭示其發(fā)生是單克隆還是獨立克隆性。對比分析雙側病灶之間以及與單側同病理類型之間蛋白表達差異。方法:9例原發(fā)性雙側乳腺癌左右組織標本共18個,對應單側乳腺癌患者乳腺組織標本10個。免疫組織化學法檢測CEA和PTEN表達情況。結果:雙側乳腺癌第一癌與第二癌和單側乳腺癌中CEA表達率分別為66.6%(6/9)、55.5%(5/9)、60%(6/10)、PTEN在第一癌、第二癌、單側乳腺癌中表達率分別為33.3%(3/9)、44.4%(4/9)、50%(5/10)、表達差異均無統(tǒng)計學意義(P0.05),雙側乳腺癌CEA中同為陽性為5例,同為陰性為3例,PTEN中同為陽性為3例,同為陰性為5例。結論:雙側乳腺癌首發(fā)癌和單側乳腺癌中CEA、PTEN蛋白的表達均無統(tǒng)計學差異。雙側乳腺癌第一癌與第二癌中CEA、PTEN蛋白的表達差異無統(tǒng)計學差異,提示雙側乳腺癌第一癌和第二癌為單克隆性。
[Abstract]:Objective: to detect the expression and expression intensity of CEA and PTEN in the paraffin sections of bilateral primary breast cancer and to reveal whether they are monoclonal or independent. The differences of protein expression between bilateral lesions and unilateral histopathological types were compared. Methods: there were 18 primary bilateral breast cancer tissues in 9 cases and 10 breast tissue specimens corresponding to unilateral breast cancer. The expression of CEA and PTEN was detected by immunohistochemistry. Results: the expression rates of CEA were 66.6% (6 / 9), 55.5% (5 / 9), 60% (6 / 10), PTEN) in the first and second breast cancers, respectively. The expression rates in unilateral breast cancer were 33.3% (3 / 9), 44.4% (4 / 9) and 50% (5 / 10), respectively. There was no significant difference (P0.05). In bilateral breast cancer, 5 cases were positive in CEA, 3 cases were negative, 3 cases were positive in PTEN and 5 cases were negative. Conclusion: there is no significant difference in the expression of CEA,PTEN protein between primary and unilateral breast cancer. There was no significant difference in the expression of CEA,PTEN protein between the first and second carcinomas of bilateral breast cancer, suggesting that the first and second carcinomas of bilateral breast cancer were monoclonal.
【學位授予單位】：遵義醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R737.9

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