【摘要】：目的探討體外沖擊波(extracorporeal shock wave,ESW)對(duì)膝骨關(guān)節(jié)炎(knee osteoarthritis,KOA)的療效及對(duì)患者血清及關(guān)節(jié)液趨化素(Chemerin)的影響。方法 60例KOA患者隨機(jī)分為ESW組(n=30)和對(duì)照組(n=30),ESW組以體外沖擊波治療,對(duì)照組以常規(guī)治療。在干預(yù)前和8周后,采用活動(dòng)時(shí)疼痛視覺(jué)模擬評(píng)分(VAS)、膝關(guān)節(jié)炎病人疼痛指數(shù)(Lequesne index)評(píng)分和美國(guó)西部Ontario與Mc Master大學(xué)骨關(guān)節(jié)炎指數(shù)(western Ontario and Mc Master osteoarthritis index,WOMAC)評(píng)分進(jìn)行評(píng)定,以及血清及關(guān)節(jié)液中Chemerin水平的變化。結(jié)果治療后,ESW組VAS、Lequesne指數(shù)評(píng)分和WOMAC骨關(guān)節(jié)炎指數(shù)評(píng)分均明顯好于對(duì)照組(P0.05)。治療后患者血清和關(guān)節(jié)液中Chemerin含量均比治療前顯著下降(P0.05或0.01);治療后ESW組血清和關(guān)節(jié)液中Chemerin含量顯著低于對(duì)照組(均P0.05)。結(jié)論膝關(guān)節(jié)液和血清中Chemerin含量反映了關(guān)節(jié)炎癥的嚴(yán)重程度,ESW治療有效的降低了血清和關(guān)節(jié)液中Chemerin含量,ESW對(duì)KOA患者治療有效,Chemerin可作為OA早期診斷及判斷嚴(yán)重程度的參考指標(biāo)。
[Abstract]:Objective To investigate the effect of extracorporeal shock wave (ESW) on knee osteoarthritis (KOA) and its influence on serum and joint fluid chemokines (Chemerin). Visual analogue pain scale (VAS), Lequesne index (LEI) and Western Ontario and Mc Master University Osteoarthritis index (WOMAC) were used to assess pain before and after exercise, as well as changes in serum and synovial fluid levels of Chemerin. Results After treatment, VAS, Lequesne index score and WOMAC Osteoarthritis Index score in ESW group were significantly better than those in control group (P 0.05). Chemerin content in serum and joint fluid in ESW group was significantly lower than that before treatment (P 0.05 or 0.01). Chemerin content in serum and joint fluid in ESW group was significantly lower than that in control group (P 0.05). The level of Chemerin in blood and serum reflects the severity of arthritis. ESW treatment effectively reduces the level of Chemerin in serum and joint fluid. ESW treatment is effective for KOA patients. Chemerin can be used as a reference index for early diagnosis and judging the severity of OA.
【作者單位】： 解放軍309醫(yī)院旃壇寺門(mén)診部;
【分類(lèi)號(hào)】：R684.3

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 侯維寧;膝骨關(guān)節(jié)炎22例誤診分析[J];實(shí)用醫(yī)學(xué)雜志;2002年01期

2 鄔強(qiáng);鄒越彬;;中藥合氫溴酸高烏甲素片治療膝骨關(guān)節(jié)炎52例[J];陜西中醫(yī);2006年05期

3 賈士軍;彭志軍;;膝骨關(guān)節(jié)炎的診治[J];山西職工醫(yī)學(xué)院學(xué)報(bào);2007年03期

4 李維;任憲石;;膝骨關(guān)節(jié)炎的治療進(jìn)展[J];中國(guó)社區(qū)醫(yī)師(醫(yī)學(xué)專(zhuān)業(yè)半月刊);2008年01期

5 楊洪文;;原發(fā)性膝骨關(guān)節(jié)炎放射學(xué)臨床觀察[J];臨床醫(yī)藥實(shí)踐;2009年11期

6 雷宇新;為膝骨關(guān)節(jié)炎患者解除痛苦[J];中老年保健;2002年05期

7 葉永平,蔣W，

本文編號(hào)：2241638