發(fā)布時(shí)間：2018-09-13 15:54

【摘要】：目的探討體外沖擊波(extracorporeal shock wave,ESW)對膝骨關(guān)節(jié)炎(knee osteoarthritis,KOA)的療效及對患者血清及關(guān)節(jié)液趨化素(Chemerin)的影響。方法 60例KOA患者隨機(jī)分為ESW組(n=30)和對照組(n=30),ESW組以體外沖擊波治療,對照組以常規(guī)治療。在干預(yù)前和8周后,采用活動時(shí)疼痛視覺模擬評分(VAS)、膝關(guān)節(jié)炎病人疼痛指數(shù)(Lequesne index)評分和美國西部Ontario與Mc Master大學(xué)骨關(guān)節(jié)炎指數(shù)(western Ontario and Mc Master osteoarthritis index,WOMAC)評分進(jìn)行評定,以及血清及關(guān)節(jié)液中Chemerin水平的變化。結(jié)果治療后,ESW組VAS、Lequesne指數(shù)評分和WOMAC骨關(guān)節(jié)炎指數(shù)評分均明顯好于對照組(P0.05)。治療后患者血清和關(guān)節(jié)液中Chemerin含量均比治療前顯著下降(P0.05或0.01);治療后ESW組血清和關(guān)節(jié)液中Chemerin含量顯著低于對照組(均P0.05)。結(jié)論膝關(guān)節(jié)液和血清中Chemerin含量反映了關(guān)節(jié)炎癥的嚴(yán)重程度,ESW治療有效的降低了血清和關(guān)節(jié)液中Chemerin含量,ESW對KOA患者治療有效,Chemerin可作為OA早期診斷及判斷嚴(yán)重程度的參考指標(biāo)。
[Abstract]:Objective To investigate the effect of extracorporeal shock wave (ESW) on knee osteoarthritis (KOA) and its influence on serum and joint fluid chemokines (Chemerin). Visual analogue pain scale (VAS), Lequesne index (LEI) and Western Ontario and Mc Master University Osteoarthritis index (WOMAC) were used to assess pain before and after exercise, as well as changes in serum and synovial fluid levels of Chemerin. Results After treatment, VAS, Lequesne index score and WOMAC Osteoarthritis Index score in ESW group were significantly better than those in control group (P 0.05). Chemerin content in serum and joint fluid in ESW group was significantly lower than that before treatment (P 0.05 or 0.01). Chemerin content in serum and joint fluid in ESW group was significantly lower than that in control group (P 0.05). The level of Chemerin in blood and serum reflects the severity of arthritis. ESW treatment effectively reduces the level of Chemerin in serum and joint fluid. ESW treatment is effective for KOA patients. Chemerin can be used as a reference index for early diagnosis and judging the severity of OA.
【作者單位】： 解放軍309醫(yī)院旃壇寺門診部;
【分類號】：R684.3

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