【摘要】：目的探討鈦合金假體表面涂層微孔孔徑和孔隙率對(duì)骨整合的影響。方法采用3D打印技術(shù)打印3種不同微孔孔徑和孔隙率的鈦合金假體,第一種假體表面微孔孔徑(260.5±34.5)μm、孔隙率68.1%,第二種孔徑(553.2±16.7)μm、孔隙率79.2%,第三種孔徑(749.8±15.0)μm、孔隙率89.0%,分別標(biāo)記為a、b、c型假體。選擇新西蘭大白兔27只,隨機(jī)分為A、B、C組各9只,分別將a、b、c型假體植入兔股骨髓腔。術(shù)后4、8、12周,每組隨機(jī)處死3只,通過Micro CT掃描觀察各組成骨情況并測(cè)量骨體積分?jǐn)?shù)(BV/TV)、組織礦物密度(TMD),通過拔出試驗(yàn)檢測(cè)各組最大拔出力。結(jié)果術(shù)后4周,各組內(nèi)植物均在位,微孔內(nèi)及周圍呈低信號(hào),無明顯沉積骨質(zhì);拔出標(biāo)本僅遠(yuǎn)端有少量未成熟骨質(zhì),表面多覆蓋纖維結(jié)締組織及陳舊血凝塊,處理標(biāo)本時(shí)可輕易洗去;三組BV/TV、TMD及最大拔出力比較差異均無統(tǒng)計(jì)學(xué)意義(P均0.05)。術(shù)后8周,各組微孔內(nèi)及周圍均見部分中密度影,為未成熟骨質(zhì),A組相對(duì)較多;三組拔出標(biāo)本遠(yuǎn)端均有明顯骨質(zhì)覆蓋,A組假體體部表面可見沉積骨質(zhì);三組間BV/TV、TMD比較差異均無統(tǒng)計(jì)學(xué)意義(P均0.05),但A組最大拔出力明顯高于B、C組(P均0.05)。術(shù)后12周,各組微孔內(nèi)及周圍均見高密度影,為沉積骨質(zhì),且伸入微孔內(nèi)部,形成鎖結(jié),A組多于B、C組,無明顯骨溶解;A組整個(gè)假體表面均勻覆蓋較多骨質(zhì),B、C組遠(yuǎn)端和近端可見明顯沉積骨質(zhì),但少于A組;A組BV/TV、TMD明顯高于B、C組(P均0.05);最大拔出力A組B組C組,組間兩兩比較P均0.05。結(jié)論鈦合金假體表面涂層微孔孔徑226~295μm、孔隙率68.1%有利于促進(jìn)骨整合,并具有較好的生物力學(xué)性能。
[Abstract]:Objective to investigate the effect of micropore diameter and porosity on bone integration on titanium alloy prosthesis. Methods three titanium alloy prostheses with different pore sizes and porosity were printed by 3D printing technique. The surface micropore size of the first prosthesis was (260.5 鹵34.5) 渭 m, the porosity was 68.1 渭 m, the second pore size was (553.2 鹵16.7) 渭 m, the porosity was 79.2 渭 m, the third pore size was (749.8 鹵15.0) 渭 m, and the porosity was 89.0B. Twenty-seven New Zealand white rabbits were randomly divided into two groups: group A (n = 9) and group C (n = 9). Three rats were randomly killed in each group at 12 weeks after operation. Osteogenesis was observed and bone volume fraction (BV/TV) was measured by Micro CT scanning. Tissue mineral density (TMD),) was used to detect the maximal pull-out force of each group by pull-out test. Results at 4 weeks after operation, the plants in each group were in position with low signal intensity in and around the micropores, and there was no obvious deposition of bone, only a small amount of immature bone was located at the distal end of the pullout specimen, and the surface was covered with fibrous connective tissue and old blood clot. The BV/TV,TMD and maximal pull-out force of the three groups were not significantly different (P < 0. 05). At 8 weeks after operation, there were some middensity shadows in and around the micropores in each group, which were relatively more in group A than in group A, and there was obvious bone overlay on the surface of the prosthesis in group A, while in group A, the depositional bone could be seen on the surface of the prosthesis. There was no significant difference in BV/TV,TMD among the three groups (P 0.05), but the maximal pull-out force of group A was significantly higher than that of group C (P 0.05). At 12 weeks after operation, there were high density shadows in and around the micropores in each group, which were deposited bone, and extended into the micropore. The formation of locked junctions in group A was more than that in group B (C). In group A, the surface of the whole prosthesis was evenly covered with more bony bone, but the BV/TV,TMD of group A was significantly higher than that of group A (P 0.05), and the maximal pull-out force was higher in group B (P 0.05) than that in group A (P < 0.05), but there was a significant difference between the two groups (P < 0.05), but the BV/TV,TMD of group A was significantly higher than that of group A (P < 0.05), while that of group A was significantly higher than that of group B (P < 0.05). Conclusion the micropore diameter of titanium alloy prosthesis coating is 226 ~ 295 渭 m, and the porosity of 68.1% is helpful to promote bone integration and has good biomechanical properties.
【作者單位】： 上海長征醫(yī)院;
【基金】：上海市教育委員會(huì)科研創(chuàng)新項(xiàng)目(15ZZ039)
【分類號(hào)】：R687.3
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本文編號(hào)：2238679