【摘要】：目的:探討影響腹腔鏡膽囊切除術后患者血液高凝狀態(tài)形成的影響因素。方法:前瞻性選擇2012年1月—2015年12月接受腹腔鏡膽囊切除術治療的患者108例為研究對象,比較術后24 h發(fā)生血液高凝狀態(tài)與未發(fā)生血液高凝狀態(tài)的患者間相關臨床因素的差異,分析術后血液高凝狀態(tài)形成的影響因素。結果:108例腹腔鏡膽囊切除術患者中,32例(29.63%)發(fā)生血液高凝狀態(tài)。與未發(fā)生血液高凝狀態(tài)的患者比較,發(fā)生血液高凝狀態(tài)的患者有高血脂病史的比例與術前收縮壓、纖維蛋白原(Fbg)、D-二聚體(D-D)、血小板計數(shù)(PLT)、凝血酶原片段(F1+F2)、轉鐵蛋白(Trf)、α-酸性糖蛋白(Orso)、C-反應蛋白(CRP)、白介素6(IL-6)、低密度脂蛋白膽固醇(LDL-C)水平明顯增高,而高密度脂蛋白膽固醇(HDL-C)水平明顯降低(均P0.05)。單因素與多因素Logistic回歸分析結果顯示,有高血脂病史、Fbg≥3.95 g/L、D-D≥100.00μg/L、PLT≥228.00×10~9/L、F1+F2≥0.16 nmol/L、Trf≥2.15 g/L、Orso≥0.85 g/L、CRP≥1.50 mg/L、IL-6≥1.50 pg/mL、LDL-C≥2.85 mg/dL是腹腔鏡膽囊切除術后患者血液高凝狀態(tài)形成的獨立危險性因素(均P0.05)。結論:對于行腹腔鏡膽囊切除術患者,如存在上述因素應注意血液高凝狀態(tài)的發(fā)生。
[Abstract]:Objective: to investigate the influencing factors of blood hypercoagulability after laparoscopic cholecystectomy (LC). Methods: 108 patients undergoing laparoscopic cholecystectomy from January 2012 to December 2015 were prospectively selected. To compare the difference of clinical factors between patients with hypercoagulability and those without hypercoagulability at 24 hours after operation, and analyze the influencing factors of blood hypercoagulability after operation. Results among 108 cases of laparoscopic cholecystectomy, 32 cases (29.63%) developed hypercoagulability. Compared with patients without hypercoagulability, patients with hypercoagulability had a history of hyperlipidemia and systolic blood pressure before operation. The levels of fibrinogen (Fbg) D-dimer (D-D), platelet count, (PLT), prothrombin fragment (F _ 1 F _ 2), transferrin (Trf), 偽 -acid glycoprotein (Orso) (Orso) (CRP), interleukin 6 (IL-6) and low density lipoprotein cholesterol (LDL-C) were significantly increased. The level of high density lipoprotein cholesterol (HDL-C) was significantly decreased (P0.05). Univariate and multivariate Logistic regression analysis showed that, With a history of hyperlipidemia, FBG 鈮，

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