【摘要】：目的觀察小劑量右美托咪定(Dex)對(duì)腹腔鏡膽囊切除術(shù)患者腎素-血管緊張素系統(tǒng)的影響。方法選擇本院40例行腹腔鏡膽囊切除術(shù)患者,采用隨機(jī)數(shù)字表分為對(duì)照組和Dex組,各20例。Dex 0.4μg/kg(Dex組)和等容量0.9%氯化鈉溶液(對(duì)照組)在誘導(dǎo)開始時(shí)泵注,泵注時(shí)間約為10 min。同時(shí)所有患者采用相同的全身麻醉誘導(dǎo)和維持方案。于麻醉誘導(dǎo)前(T0)、切皮前(T1)、氣腹后5 min(T2)、10 min(T3)、20 min(T4)、拔管后1min(T5)、5 min(T6)、10 min(T7)記錄收縮壓(SBP)、心率(HR);每組中有10例患者在T0、T2、T4、T5自非輸液側(cè)靜脈留置針抽取靜脈血3 ml,測(cè)定血漿腎素活性及血管緊張素Ⅱ水平;記錄睜眼時(shí)間、拔管時(shí)間、術(shù)后疼痛視覺模擬評(píng)分(VAS);于T5~T7記錄Ramsay評(píng)分。結(jié)果 Dex組T6、T7 SBP低于對(duì)照組(P0.05);Dex組VAS低于對(duì)照組(P0.05)。兩組患者睜眼時(shí)間、拔管時(shí)間、Ramsay鎮(zhèn)靜評(píng)分比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論誘導(dǎo)時(shí)應(yīng)用小劑量Dex可以維持圍術(shù)期血流動(dòng)力學(xué)平穩(wěn),不延長(zhǎng)患者睜眼時(shí)間及拔管時(shí)間,可降低術(shù)后VAS。小劑量Dex(0.4μg/kg)對(duì)腎素-血管緊張素系統(tǒng)無顯著影響。
[Abstract]:Objective to observe the effect of low dose dexmetidine (Dex) on renin-angiotensin system in patients undergoing laparoscopic cholecystectomy. Methods 40 patients undergoing laparoscopic cholecystectomy in our hospital were randomly divided into two groups: control group (n = 20) and Dex group (n = 20). Each of them was injected with 0.9% sodium chloride solution (Dex group) and 0.9% sodium chloride solution of equal volume at the beginning of induction. The time of injection was about 10 min.. At the same time, all patients were treated with the same general anesthesia induction and maintenance regimen. Before anesthesia induction (T 0), before skin incision (T 1), 5 min (T 2) after pneumoperitoneum (T 2) 10 min (T 3) 20 min (T 4), 1min (T 5) 5 min (T 6) 10 min (T 7) after extubation, systolic pressure (SBP), heart rate (HR); was recorded in 10 patients in each group. Angiotensin 鈪，

本文編號(hào)：2199929