【摘要】：目的探討高壓氧與尼莫地平、依達拉奉聯(lián)合治療重型顱腦損傷的效果及安全性。方法回顧性分析78例重型顱腦損傷患者的臨床資料,根據(jù)治療方法的不同分為兩組,每組39例。對照組接受常規(guī)方案,加高壓氧治療;觀察組實施高壓氧與尼莫地平、依達拉奉聯(lián)合治療。對兩組患者療效、格拉斯哥昏迷評分(GCS)及并發(fā)癥情況進行觀察。結(jié)果觀察組治療后總有效率為92.31%,與對照組(76.92%)相比,差異存在統(tǒng)計學意義(P0.05);兩組患者不同時間GCS顯示,入院時及治療第1天兩組GCS無明顯變化,治療第14、28天,兩組患者GCS均有不同程度上升,觀察組均高于對照組,差異有統(tǒng)計學意義(P0.05);觀察組治療后不良反應(yīng)發(fā)生率12.82%,對照組為10.26%,兩組差異無統(tǒng)計學意義(P0.05)。結(jié)論重型顱腦損傷采取高壓氧與尼莫地平、依達拉奉聯(lián)合治療具有較好療效,能降低致殘率及病死率,治療安全性高,利于患者盡早康復,值得推廣。
[Abstract]:Objective to investigate the efficacy and safety of hyperbaric oxygen combined with nimodipine and Edaravone in the treatment of severe craniocerebral injury. Methods the clinical data of 78 patients with severe craniocerebral injury were analyzed retrospectively. The control group was treated with hyperbaric oxygen plus hyperbaric oxygen, and the observation group was treated with Nimodipine and Edaravone. The curative effect, Glasgow coma score (GCS) and complications were observed. Results the total effective rate was 92.31% in the observation group, which was significantly different from that in the control group (76.92%) (P0.05), the GCS of the two groups at different time showed no significant change on admission and on the first day of treatment, and on the 14th day of treatment, there was no significant change in GCS in the two groups. The GCS of the two groups increased in varying degrees, the observation group was higher than the control group, the difference was statistically significant (P0.05); the incidence of adverse reactions after treatment in the observation group was 12.82, and that in the control group was 10.26. There was no significant difference between the two groups (P0.05). Conclusion Hyperbaric oxygen combined with nimodipine and Edaravone is effective in treating severe craniocerebral injury. It can reduce the rate of disability and mortality, and is safe for patients to recover as soon as possible. It is worth popularizing.
【作者單位】： 四川省達州市第二人民醫(yī)院神經(jīng)外科;重慶醫(yī)科大學附屬第一醫(yī)院神經(jīng)外科;
【基金】：重慶市科委前沿與應(yīng)用基礎(chǔ)研究項目資助(cstc2014jcyjA10009)
【分類號】：R651.15

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8 任紅O，

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