【摘要】：目的探討不同阿片類受體對(duì)鹽酸氫考酮引起小鼠高活動(dòng)性和鎮(zhèn)痛過程的影響。方法采用小鼠自主活動(dòng)測(cè)定和小鼠熱板鎮(zhèn)痛的實(shí)驗(yàn)方法研究μ、δ、κ3種阿片在鹽酸氫考酮引起小鼠高活動(dòng)性的不同作用。結(jié)果不同劑量的鹽酸氫考酮均能夠誘發(fā)小鼠的自發(fā)活動(dòng)明顯增加,且呈顯著的量效關(guān)系(P0.05)。非選擇性阿片受體拮抗劑能夠劑量依賴性地降低鹽酸氫考酮引起的小鼠自發(fā)活動(dòng)增加(P0.05)。選擇性μ受體拮抗劑對(duì)鹽酸氫考酮引起的小鼠自發(fā)活動(dòng)增加無影響,而選擇性δ受體拮抗劑能夠劑量依賴性地降低鹽酸氫考酮引起的小鼠自發(fā)活動(dòng)增加(P0.05)。選擇性κ受體拮抗劑能夠增強(qiáng)鹽酸氫考酮引起的小鼠自發(fā)活動(dòng)增加。選擇性μ受體拮抗劑和選擇性δ受體拮抗劑對(duì)小鼠無鎮(zhèn)痛作用,而選擇性κ受體拮抗劑能夠拮抗鹽酸氫考酮的鎮(zhèn)痛作用。結(jié)論鹽酸氫考酮引起的小鼠自發(fā)活動(dòng)增加的作用可能通過δ受體介導(dǎo),而其鎮(zhèn)痛作用則可能是通過κ受體介導(dǎo)。
[Abstract]:Objective to investigate the effects of different opioid receptors on hyperactivity and analgesia induced by hydrocodone hydrochloride in mice. Methods the effects of 渭, 未 and 魏 on the hyperactivity induced by hydrocodone in mice were studied by the methods of spontaneous activity determination in mice and hot plate analgesia in mice. Results the spontaneous activity of mice induced by different doses of hydrocodone was significantly increased (P0.05). Non-selective opioid receptor antagonists could reduce the increase of spontaneous activity induced by hydrocodone hydrochloride in a dose-dependent manner (P0.05). Selective 渭 receptor antagonist had no effect on the increase of spontaneous activity induced by hydrocodone in mice, but selective 未 receptor antagonist could decrease the increase of spontaneous activity of mice induced by hydrocodone in a dose-dependent manner (P0.05). Selective 魏 receptor antagonists can enhance the spontaneous activity induced by hydrocodone hydrochloride in mice. Selective 渭 receptor antagonists and selective 未 receptor antagonists had no analgesic effect on mice, but selective 魏 receptor antagonists could antagonize the analgesic effect of hydrocodone hydrochloride. Conclusion the increase of spontaneous activity induced by hydrocodone hydrochloride in mice may be mediated by 未 receptor and its analgesic effect may be mediated by 魏 receptor.
【作者單位】： 安徽醫(yī)科大學(xué)附屬省立醫(yī)院麻醉科;
【分類號(hào)】：R614
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本文編號(hào)：2165159