發(fā)布時間：2018-08-04 15:40

【摘要】：背景:關于胸椎段腫瘤生物力學方面的研究比較多,但是有關有限元分析胸腰段椎體血管瘤骨折風險的研究不多。目的:建立胸腰段椎體血管瘤有限元模型,分析其生物力學分布特點,評估脊椎血管瘤的骨折風險。方法:建立T_(12)-L_2椎體的正常椎體、血管瘤椎體(血管瘤占椎體松質(zhì)骨比例分別為20%,40%,60%,80%)、骨水泥填充椎體三維有限元模型,并進行力學分析。分別予以600 N垂直靜態(tài)壓力下正常椎體、血管瘤椎體、骨水泥填充的椎體等效應力分布及特點。結(jié)果與結(jié)論:(1)建立了有效的T_(12)-L_2椎體有限元模型。在靜態(tài)壓力作用下3組模型L_1椎體皮質(zhì)骨應力傳導無明顯差異,應力最大部均出現(xiàn)在椎弓根基底部、關節(jié)突關節(jié)及峽部;(2)在骨皮質(zhì)完整情況下,椎體血管瘤占椎體松質(zhì)骨20%-40%時病變椎體與正常椎體應力分布無統(tǒng)計學差異;當比例為60%-80%時,病變椎體與正常椎體應力分布有統(tǒng)計學差異;(3)建立的胸腰段三維有限元模型具有可用性;生物力學實驗顯示,椎體皮質(zhì)骨完整性、松質(zhì)骨破壞比例是椎體血管瘤骨折風險關鍵因素。
[Abstract]:Background: much research has been done on the biomechanics of thoracic vertebrae, but there are few studies on the risk of thoracolumbar vertebral hemangioma fracture by finite element analysis. Objective: to establish a finite element model of thoracolumbar vertebral hemangioma, analyze its biomechanical distribution and evaluate the fracture risk of spinal hemangioma. Methods: the normal vertebral body of T _ (12) -L _ 2 was established. The vertebral body of hemangioma (the proportion of hemangioma to cancellous bone of vertebral body was 204040%), the three-dimensional finite element model of vertebral body was filled with bone cement, and the mechanical analysis was carried out. The distribution and characteristics of equivalent stress of normal vertebral body, hemangioma vertebral body and bone cement filled vertebral body were given under 600 N vertical static pressure. Results and conclusions: (1) an effective finite element model of T _ (12) -L _ 2 vertebrae was established. Under static pressure, there was no significant difference in stress conduction of L1 vertebra cortical bone in the three groups. The maximum stress appeared at the base of pedicle, articular process and isthmus. (2) under the condition of complete bone cortex, the stress of the three groups appeared at the base of pedicle, articular process and isthmus. There was no significant difference in stress distribution between vertebral body and normal vertebra when 20% -40% of vertebral cancellous bone was occupied by vertebral hemangioma, and when the proportion was 60% -80%, there was no significant difference in stress distribution between vertebral body and normal vertebral body. The stress distribution of diseased vertebral body and normal vertebral body is statistically different. (3) the three-dimensional finite element model of thoracolumbar segment is available; the biomechanical experiment shows that the cortical bone integrity of vertebral body is intact. The ratio of cancellous bone destruction is a key risk factor for vertebral hemangioma fracture.
【作者單位】： 新疆醫(yī)科大學附屬腫瘤醫(yī)院骨與軟組織病區(qū);
【基金】：國家自然科學基金項目(81360282)~~
【分類號】：R738

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