骨密度與老年髖部骨折三維有限元模型密度的相關(guān)性分析
發(fā)布時間：2018-08-03 14:26
【摘要】：目的：探討骨密度與老年髖部骨折股骨近端三維有限元模型密度的關(guān)系,通過計算機mimics軟件有限元建模,對不同年齡層次老年骨折病例的髖部骨密度變化進行分析,驗證比對,探討有效預(yù)判髖部骨折的部位類型和高危人群的方法和規(guī)律。方法：1.選取8例老年髖部骨折,60至90歲老年女患者,排除嚴重心肺疾病以及代謝性疾病,排除中風及小兒麻痹病史,其中4例股骨頸骨折,4例股骨轉(zhuǎn)子間骨折；左側(cè)肢體3例,右側(cè)肢體5例。2.分別測定各例腰椎骨密度,并收集各例雙側(cè)髖關(guān)節(jié)的GE64排螺旋CT影像資料(以DICOM格式數(shù)據(jù)保存),運用Mimics 15.01軟件在電腦對健側(cè)股骨近端通過骨組織閾值分割、區(qū)域增長、腔隙填充、編輯蒙罩、三維重建功能、網(wǎng)格劃分及材料賦值等步驟,自動生成的三維立體圖像,并通過包裹、光滑等操作工具對模型進行光順,構(gòu)建生理特性接近健側(cè)股骨近端的三維有限元模型,將建立的三維有限元模型導(dǎo)入abaqus軟件,根據(jù)材料屬性的模型以及經(jīng)驗公式,自動計算出該模型的最終可獲得該模型密度。最后應(yīng)用SPSS18.0軟件對數(shù)據(jù)進行統(tǒng)計學(xué)分析,得出結(jié)論。成果：1.腰椎骨密度的平均值及方差分析：股骨頸骨折組的腰椎骨密度為(-3.15±0.54)g/cm2,股骨轉(zhuǎn)子間骨折組的腰椎骨密度為(-4.05±0.24)g/cm2,兩組骨密度差異具有統(tǒng)計學(xué)意義(t=3.046,P=0.02)。2.實驗?zāi)Ｐ兔芏绕骄导胺讲罘治觯汗晒穷i骨折組實驗?zāi)Ｐ兔芏葹?1.34±0.06)×106,股骨轉(zhuǎn)子間骨折組的密度為(1.15±0.02)×106,兩組實驗?zāi)Ｐ兔芏炔町惥哂薪y(tǒng)計學(xué)意義(t=6.0083,P=0.03)。3.骨密度儀測腰椎的BMD值與股骨實驗?zāi)Ｐ兔芏戎党删�性正相關(guān),r=0.881,P=0.004)。結(jié)論：1.通過Minics15.01的三維重建及Abaqus6.12的有限元分析,進行區(qū)域劃分,控制網(wǎng)格的質(zhì)量及數(shù)量,應(yīng)用合理的材料賦值法,對模型區(qū)域分配的材料屬性與股骨近端的真實屬性相似,建立更加接近股骨近端生理解剖特點的三維有限元模型。2.根據(jù)統(tǒng)計結(jié)果,骨密度儀測腰椎的BMD值與股骨實驗?zāi)Ｐ兔芏戎党删�性正相關(guān),提示骨密度與老年髖部骨折股骨近端三維有限元模型密度成線性正相關(guān)的關(guān)系,可為進一步用有限元分析法探討老年髖部骨折部位與骨密度的關(guān)系提供理論依據(jù),預(yù)判髖部骨折高危人群的方法和規(guī)律。
[Abstract]:Objective: to investigate the relationship between bone mineral density (BMD) and the density of proximal femur in elderly patients with hip fracture. Objective: to study the methods and rules of predicting hip fracture site and high-risk population. Method 1: 1. Eight elderly women aged 60 to 90 years old with hip fracture were selected to exclude severe cardiopulmonary disease and metabolic disease, as well as a history of stroke and poliomyelitis, including 4 cases of femoral neck fracture and 4 cases of femoral intertrochanteric fracture, and 3 cases of left limb. Right extremity 5 cases. 2. Bone mineral density (BMD) of lumbar vertebrae was measured, and GE64 spiral CT images of bilateral hip joint were collected (stored in DICOM format). The bone tissue threshold was segmented by Mimics 15.01 software to segment the proximal end of the contralateral femur, and the area increased. Space filling, editing mask, 3D reconstruction function, mesh division and material assignment, etc., automatically generate 3D stereo image, and smooth the model by wrapping, smoothing and other operating tools. A three-dimensional finite element model with physiological characteristics close to the proximal end of the contralateral femur was constructed. The established three-dimensional finite element model was imported into abaqus software. According to the model of material properties and empirical formula, the final density of the model was calculated automatically. Finally, the statistical analysis of the data is made by SPSS18.0 software, and the conclusion is drawn. Result: 1. Analysis of variance of lumbar bone mineral density: the BMD of lumbar vertebrae was (-3.15 鹵0.54) g / cm ~ (-2) in femoral neck fracture group and (-4.05 鹵0.24) g / cm ~ (2) in femoral intertrochanteric fracture group. The average density of experimental model and the analysis of variance: the density of experimental model was (1.34 鹵0.06) 脳 106 in femoral neck fracture group and (1.15 鹵0.02) 脳 10 ~ (6) in femoral intertrochanteric fracture group. The BMD of lumbar vertebrae was positively correlated with the density of femur model by BMD. Conclusion 1. Through the 3D reconstruction of Minics15.01 and the finite element analysis of Abaqus6.12, the area is divided, the quality and quantity of the mesh are controlled, and the material attribute of the model area is similar to the real attribute of the proximal femur by using the reasonable material assignment method. A three-dimensional finite element model. 2. 2 was established, which is closer to the physiological and anatomical characteristics of proximal femur. According to the statistical results, the BMD of lumbar vertebrae measured by BMD was positively correlated with the density of femur experimental model, suggesting that BMD was positively correlated with the density of 3D finite element model of proximal femur of hip fracture in elderly patients. It can provide theoretical basis for further study on the relationship between hip fracture site and bone mineral density by finite element analysis, and predict the method and rule of high risk population of hip fracture.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R683
[Abstract]:Objective: to investigate the relationship between bone mineral density (BMD) and the density of proximal femur in elderly patients with hip fracture. Objective: to study the methods and rules of predicting hip fracture site and high-risk population. Method 1: 1. Eight elderly women aged 60 to 90 years old with hip fracture were selected to exclude severe cardiopulmonary disease and metabolic disease, as well as a history of stroke and poliomyelitis, including 4 cases of femoral neck fracture and 4 cases of femoral intertrochanteric fracture, and 3 cases of left limb. Right extremity 5 cases. 2. Bone mineral density (BMD) of lumbar vertebrae was measured, and GE64 spiral CT images of bilateral hip joint were collected (stored in DICOM format). The bone tissue threshold was segmented by Mimics 15.01 software to segment the proximal end of the contralateral femur, and the area increased. Space filling, editing mask, 3D reconstruction function, mesh division and material assignment, etc., automatically generate 3D stereo image, and smooth the model by wrapping, smoothing and other operating tools. A three-dimensional finite element model with physiological characteristics close to the proximal end of the contralateral femur was constructed. The established three-dimensional finite element model was imported into abaqus software. According to the model of material properties and empirical formula, the final density of the model was calculated automatically. Finally, the statistical analysis of the data is made by SPSS18.0 software, and the conclusion is drawn. Result: 1. Analysis of variance of lumbar bone mineral density: the BMD of lumbar vertebrae was (-3.15 鹵0.54) g / cm ~ (-2) in femoral neck fracture group and (-4.05 鹵0.24) g / cm ~ (2) in femoral intertrochanteric fracture group. The average density of experimental model and the analysis of variance: the density of experimental model was (1.34 鹵0.06) 脳 106 in femoral neck fracture group and (1.15 鹵0.02) 脳 10 ~ (6) in femoral intertrochanteric fracture group. The BMD of lumbar vertebrae was positively correlated with the density of femur model by BMD. Conclusion 1. Through the 3D reconstruction of Minics15.01 and the finite element analysis of Abaqus6.12, the area is divided, the quality and quantity of the mesh are controlled, and the material attribute of the model area is similar to the real attribute of the proximal femur by using the reasonable material assignment method. A three-dimensional finite element model. 2. 2 was established, which is closer to the physiological and anatomical characteristics of proximal femur. According to the statistical results, the BMD of lumbar vertebrae measured by BMD was positively correlated with the density of femur experimental model, suggesting that BMD was positively correlated with the density of 3D finite element model of proximal femur of hip fracture in elderly patients. It can provide theoretical basis for further study on the relationship between hip fracture site and bone mineral density by finite element analysis, and predict the method and rule of high risk population of hip fracture.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R683
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