三黃湯灌注聯(lián)合負(fù)壓封閉引流技術(shù)治療體表膿腫（潰破期）的臨床研究
發(fā)布時(shí)間：2018-07-23 18:33
【摘要】：目的:觀察三黃湯灌注聯(lián)合負(fù)壓封閉引流技術(shù)(VSD)對(duì)體表膿腫(潰破期)創(chuàng)面愈合的影響,并分析和探討其可能的作用機(jī)理。方法:本研究采用前瞻性隨機(jī)對(duì)照設(shè)計(jì)方案,選取2013年06月~2017年02月我科治療且符合納入標(biāo)準(zhǔn)的72例患者,采用隨機(jī)數(shù)字表法隨機(jī)分為3組,單純中藥組24例、單純VSD組24例、聯(lián)合組24例。單純中藥組僅采用三黃湯持續(xù)外敷,單純VSD組僅采用生理鹽水和VSD持續(xù)灌注沖洗,而聯(lián)合組則采用三黃湯和VSD持續(xù)灌注沖洗。觀察三組患者不同時(shí)間段創(chuàng)面創(chuàng)腔面積縮小率、創(chuàng)面肉芽生長(zhǎng)情況、疼痛程度及炎性相關(guān)檢查等指標(biāo)。采用統(tǒng)計(jì)學(xué)方法分析比較三組患者的相應(yīng)觀察指標(biāo)。結(jié)果:本研究患者均得到隨訪,無脫落或剔除現(xiàn)象。在創(chuàng)面創(chuàng)腔縮小情況方面,三組患者創(chuàng)面創(chuàng)腔面積縮小率均有所提高,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),且聯(lián)合組分別與單純中藥組和單純VSD組的患者比較也存在差異(P0.05);在肉芽生長(zhǎng)方面,三組患者創(chuàng)面評(píng)分均有所提高,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),且聯(lián)合組分別與單純中藥組和單純VSD組的患者比較也存在差異(P0.05);在疼痛改善方面,三組術(shù)后第1d、5d、10d、15d的VAS改善均有統(tǒng)計(jì)學(xué)的差異(P0.05),術(shù)后10d、15d聯(lián)合組分別與單純中藥組和單純VSD組的患者VAS改善比較也存在差異(P0.05);在炎性反應(yīng)的方面,第1d、3d、5d、10d和15d的WBC計(jì)數(shù)、CRP含量和ESR含量改善具有統(tǒng)計(jì)學(xué)的差異(P0.05),術(shù)后5d、10d、15d聯(lián)合組分別與單純中藥組和單純VSD組的炎性反應(yīng)改善比較也存在差異(P0.05)。結(jié)論:三黃湯聯(lián)合VSD用于促進(jìn)創(chuàng)面愈合方面,其效果優(yōu)于單純應(yīng)用三黃湯外敷或單純VSD;三黃湯灌注與VSD技術(shù)創(chuàng)新性的有機(jī)結(jié)合治療體表膿腫(潰破期)突出了傳統(tǒng)中醫(yī)外科治療方法與現(xiàn)代醫(yī)學(xué)臨床技術(shù)進(jìn)行有機(jī)結(jié)合的可行性,為外科體表膿腫(潰破期)的治療提供一種新的操作簡(jiǎn)單、理論可行的治療方法。
[Abstract]:Objective: to observe the effect of Sanhuang decoction perfusion combined with negative pressure blocking drainage (VSD) on wound healing of body surface abscess (ulceration), and to analyze its possible mechanism. Methods: a prospective randomized controlled design was used in this study. 72 patients who were treated by our department from June 2013 to February 2017 were randomly divided into three groups: Chinese medicine group (n = 24) and VSD group (n = 24). Combined group 24 cases. The traditional Chinese medicine group was only treated with Sanhuang decoction for external application, the simple VSD group was only irrigated with normal saline and VSD, while the combined group was irrigated with Sanhuang decoction and VSD. The reduction rate of wound cavity area, granulation growth, pain degree and inflammatory correlation examination were observed in three groups. Statistical method was used to analyze and compare the corresponding observation indexes of the three groups. Results: all the patients in this study were followed up. In the wound cavity reduction, the wound area reduction rate of the three groups increased, the difference was statistically significant (P0.05), and the combined group compared with the traditional Chinese medicine group and the simple VSD group patients were also different (P0.05); in the granulation growth, The wound score of the three groups were improved, the difference was statistically significant (P0.05), and there were differences between the combined group and the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in the improvement of VAS between the three groups on the 1st day, the 5th day, the 10th day and the 15th day after operation (P0.05). The improvement of VAS in the combined group was also different from that in the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in WBC content and ESR content between 10 and 15 days after operation (P0.05), and there was also significant difference in inflammatory response between the combined group and the traditional Chinese medicine group and the simple VSD group on the 5th day after operation (P0.05). Conclusion: Sanhuang decoction combined with VSD can promote wound healing. The effect is better than that of using Sanhuang decoction for external application or VSD alone, and the innovative combination of perfusion and VSD technology in the treatment of surface abscess (rupture stage) highlights the traditional Chinese medicine surgical treatment method and modern medical clinical technology in the treatment of body surface abscess. The feasibility of organic integration, To provide a new simple and theoretical method for the treatment of surgical surface abscess.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R632.5
本文編號(hào)：2140261
[Abstract]:Objective: to observe the effect of Sanhuang decoction perfusion combined with negative pressure blocking drainage (VSD) on wound healing of body surface abscess (ulceration), and to analyze its possible mechanism. Methods: a prospective randomized controlled design was used in this study. 72 patients who were treated by our department from June 2013 to February 2017 were randomly divided into three groups: Chinese medicine group (n = 24) and VSD group (n = 24). Combined group 24 cases. The traditional Chinese medicine group was only treated with Sanhuang decoction for external application, the simple VSD group was only irrigated with normal saline and VSD, while the combined group was irrigated with Sanhuang decoction and VSD. The reduction rate of wound cavity area, granulation growth, pain degree and inflammatory correlation examination were observed in three groups. Statistical method was used to analyze and compare the corresponding observation indexes of the three groups. Results: all the patients in this study were followed up. In the wound cavity reduction, the wound area reduction rate of the three groups increased, the difference was statistically significant (P0.05), and the combined group compared with the traditional Chinese medicine group and the simple VSD group patients were also different (P0.05); in the granulation growth, The wound score of the three groups were improved, the difference was statistically significant (P0.05), and there were differences between the combined group and the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in the improvement of VAS between the three groups on the 1st day, the 5th day, the 10th day and the 15th day after operation (P0.05). The improvement of VAS in the combined group was also different from that in the traditional Chinese medicine group and the simple VSD group (P0.05). There were significant differences in WBC content and ESR content between 10 and 15 days after operation (P0.05), and there was also significant difference in inflammatory response between the combined group and the traditional Chinese medicine group and the simple VSD group on the 5th day after operation (P0.05). Conclusion: Sanhuang decoction combined with VSD can promote wound healing. The effect is better than that of using Sanhuang decoction for external application or VSD alone, and the innovative combination of perfusion and VSD technology in the treatment of surface abscess (rupture stage) highlights the traditional Chinese medicine surgical treatment method and modern medical clinical technology in the treatment of body surface abscess. The feasibility of organic integration, To provide a new simple and theoretical method for the treatment of surgical surface abscess.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R632.5
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 陳奎銘;王小平;蔡惠群;;中醫(yī)中藥治療糖尿病足潰瘍的臨床研究近況[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2017年04期
2 王霄;柳越冬;;中醫(yī)瘍科主要學(xué)術(shù)流派及思想探析[J];長(zhǎng)春中醫(yī)藥大學(xué)學(xué)報(bào);2016年05期
3 尹麗麗;;黃連的藥理作用及現(xiàn)代研究進(jìn)展[J];中醫(yī)臨床研究;2016年28期
4 曾鴻孟;唐乾利;;體表慢性難愈合創(chuàng)面的研究進(jìn)展[J];中國(guó)燒傷創(chuàng)瘍雜志;2016年05期
5 趙飛燕;;五倍子的藥理作用研究[J];世界最新醫(yī)學(xué)信息文摘;2016年68期
6 李升偉;;新醫(yī)學(xué)時(shí)代:治療性基因組編輯[J];世界科學(xué);2016年08期
7 馮靜;鄧菲;段華;;水晶丹外敷治療急性蜂窩組織炎的療效觀察[J];實(shí)用醫(yī)院臨床雜志;2016年04期
8 張傳毅;孫莉娜;楊向東;陳國(guó)富;梁軍波;;下肢開放骨折患者術(shù)后感染病原菌與負(fù)壓封閉引流治療分析[J];中華醫(yī)院感染學(xué)雜志;2016年10期
9 蔡艷;;苦參素藥理作用研究進(jìn)展[J];實(shí)用中醫(yī)藥雜志;2016年04期
10 胡麗芳;;三黃湯濕敷治療護(hù)理皮膚軟組織損傷的臨床觀察[J];基層醫(yī)學(xué)論壇;2016年11期
，本文編號(hào)：2140261
本文鏈接：http://sikaile.net/yixuelunwen/waikelunwen/2140261.html
最近更新
教材專著
