【摘要】：目的探討骨內(nèi)炎癥性肌纖維母細(xì)胞性腫瘤(inflammatory myofibroblastic tumor,IMT)的臨床病理特征、免疫表型、診斷及鑒別診斷。方法采用HE、免疫組化En Vision兩步法染色對(duì)4例骨內(nèi)IMT的臨床病理學(xué)特征進(jìn)行分析并復(fù)習(xí)相關(guān)文獻(xiàn)。結(jié)果 4例IMT中女性1例,男性3例,發(fā)生于脛骨、股骨各2例,其中3例同時(shí)累及骨及軟組織。組織學(xué)上由肌纖維母細(xì)胞樣梭形細(xì)胞增生伴漿細(xì)胞、淋巴細(xì)胞、嗜酸性粒細(xì)胞等炎細(xì)胞浸潤(rùn)。免疫表型:vimentin、SMA、actin、H-caldesmon、CD34均呈陽(yáng)性,部分細(xì)胞表達(dá)CD68。結(jié)論 IMT是具有局部侵襲性的交界性腫瘤,臨床較罕見(jiàn),應(yīng)與一些良性及惡性的軟組織腫瘤及腫瘤樣病變鑒別。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of intraosseous inflammatory myofibroblastoma (inflammatory myofibroblastic tumorus). Methods the clinicopathological features of 4 cases of intraosseous IMT were analyzed by HEand en Vision two-step immunohistochemical staining and the relevant literatures were reviewed. Results of the 4 cases, 1 was female and 3 were male, which occurred in tibia and femur in 2 cases, 3 of which involved bone and soft tissue at the same time. Histologically, myofibroblast-like spindle cells proliferate with inflammatory cells such as plasma cells, lymphocytes, eosinophils, etc. The immunophenotype of SMAactinin H-caldesmonn was positive, and some of the cells expressed CD68. Conclusion IMT is a borderline tumor with local invasion, which is rare in clinic and should be distinguished from some benign and malignant soft tissue tumors and tumor-like lesions.
【作者單位】： 北京積水潭醫(yī)院病理科;北京積水潭醫(yī)院骨腫瘤科;
【分類號(hào)】：R738

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本文編號(hào)：2139029